Protein Info for CA265_RS00660 in Pedobacter sp. GW460-11-11-14-LB5

Updated annotation (from data): uvrA paralog in Bacteroidetes
Rationale: Very important for resisting cisplatin. Both the "standard" uvrA and this gene were important for cisplatin resistance. (SEED_correct)
Original annotation: excinuclease ABC subunit A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 937 TIGR00630: excinuclease ABC subunit A" amino acids 13 to 917 (905 residues), 1135.4 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 141 to 255 (115 residues), 65.3 bits, see alignment E=1.3e-21 PF17755: UvrA_DNA-bind" amino acids 302 to 365 (64 residues), 46.6 bits, see alignment 1.2e-15

Best Hits

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 63% identity to gfo:GFO_1787)

Predicted SEED Role

"Excinuclease ABC subunit A paralog in greater Bacteroides group" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YZD8 at UniProt or InterPro

Protein Sequence (937 amino acids)

>CA265_RS00660 uvrA paralog in Bacteroidetes (Pedobacter sp. GW460-11-11-14-LB5)
MSKKEAEKDPHKNIIIKGARVHNLKNIDVAIPKNKLVVVTGMSGSGKSSLAFDTLYAEGQ
RRYVESLSSYARQFMGRMNKPDVDYIKGIAPAIAIEQKVITSNPRSTVGTSTEIYDYLKL
LFSRIGKTISPVSGKEVKKDSVSTVVDYVNAMPEDTTVTIFCPLYPHNNRTIKEELAILL
QKGFLRVLINDKIEKIETVLDDADFKDAELTDDKTVQILIDRIVTNQEEETLSRLADSAQ
TAFFEGKGDCYVEAQGTTKHFSDRFELDGIKFEEPTPNFFSFNNPYGACKRCEGYGNVIG
IDEDLVIPDKSKSVYDNAIAPWRGEKMNVWLQNFIKAAPKFEFPIHRPYSALTETEQQLL
WTGNKYFAGLDAFFKELEEQTYKIQYRVMLSRYRGKTTCPDCKGSRLRKDASYVKIAEKS
IIDVVLMPLAKALVFFNELKLNTNDTKIAKRLLAEIDNRFLYLNNVGLGYLTLNRLSNTL
SGGESQRINLATSLGSSLVGSIYVLDEPSIGLHPRDTNKLIEVLISLRNVGNTVLVVEHE
EEMMRAADYIIDIGPEAGTHGGNLVFSGNYEEILKDKNSLTGRYLSGLEKIAIPDKRRKW
KDHILIKGARENNLQNIDVKFPLGVFTAVSGVSGSGKTSLVKKILYPALQKAIGNYAGEQ
TGAYDGIFGNYDLVSAVEMVDQNPIGRSSRSNPVTYVKAWDDIRALFSGLASAKAAGLKP
AAFSFNVEGGRCDVCQGEGEVKIEMQFMADIYLPCEACNGKRFKQQVLDVTYKEKNVSEI
LDMTIEEAVEFFKDEQKILNKLNPLVDVGLGYVHLGQSSNTLSGGEAQRIKLASFLIKGN
NANKTLFIFDEPTTGLHFHDIKKLLKALNTLIEQGNTILVIEHNMDMIKCADWVIDIGPE
GGDGGGQVVFEGIPEDLVQVEKSYTGKYLASHLNLNP