Protein Info for CA265_RS00240 in Pedobacter sp. GW460-11-11-14-LB5
Annotation: histidine kinase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 77% identity to phe:Phep_2504)Predicted SEED Role
"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)
Isozymes
Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-
Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1X9YZH4 at UniProt or InterPro
Protein Sequence (376 amino acids)
>CA265_RS00240 histidine kinase (Pedobacter sp. GW460-11-11-14-LB5) MEEEQKEESVRHFLDLVKKSRRGKLKIYIGMSAGVGKTYRMLQESHALLRNGVDICIGYV ETHKRAETEALVAGLPIIPRRKIFYRGKEIEEMDLKGIMNRHPEIVIVDELAHSNAEGSK NTKRWQDVFDLLEAGISVISAVNIQHLESINEEIEQITGIAVTERIPDKILEIADEIVNI DLTADELVTRLKEGKIYDQSKIERALGNFFQSDKILQLRELALKEVVHQVERKIQTEIPK SIKLRPERFLACISSNAETAGVVIRKTARLASYYRSPWIVLYVQSDSESMERIKLDKQRH LINHFKLATELGAEVIKVKSNGITKTIIDVATEKEITTICIGKPHLNIFQVILRTAVFNG LLKNLAMKDIDLVILS