Protein Info for BWI76_RS27855 in Klebsiella michiganensis M5al

Annotation: D-serine transporter DsdX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 30 to 48 (19 residues), see Phobius details amino acids 58 to 77 (20 residues), see Phobius details amino acids 101 to 129 (29 residues), see Phobius details amino acids 141 to 166 (26 residues), see Phobius details amino acids 178 to 198 (21 residues), see Phobius details amino acids 226 to 246 (21 residues), see Phobius details amino acids 259 to 282 (24 residues), see Phobius details amino acids 302 to 322 (21 residues), see Phobius details amino acids 343 to 371 (29 residues), see Phobius details amino acids 385 to 408 (24 residues), see Phobius details amino acids 420 to 444 (25 residues), see Phobius details TIGR00791: transporter, gluconate:H+ symporter (GntP) family" amino acids 5 to 445 (441 residues), 555.3 bits, see alignment E=5.6e-171 PF02447: GntP_permease" amino acids 7 to 444 (438 residues), 534.9 bits, see alignment E=7.6e-165

Best Hits

Swiss-Prot: 91% identical to DSDX_ECOL6: D-serine transporter DsdX (dsdX) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K13629, D-serine transporter (inferred from 94% identity to kpe:KPK_0020)

Predicted SEED Role

"D-serine permease DsdX" in subsystem Glycine and Serine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AV74 at UniProt or InterPro

Protein Sequence (445 amino acids)

>BWI76_RS27855 D-serine transporter DsdX (Klebsiella michiganensis M5al)
MESQIWVVSTLLISIVLIVLTIVKLKFHPFLALLLASFFVGAMMGMSPLDMVNAIESGIG
GTLGFLAAVIGLGTILGKMMEVSGAAERIGLTLQRCRWLSADVIMVLVGLICGITLFVEV
GVVLLIPLAFSIAKKTNTSLLKLAIPLCTALMAVHCVVPPHPAALFVANKLGADIGTVIV
YGLLVGLLASLVGGPLFLRLLGNRLPFKAVPAEFANLEVRKEETLPSLGATLFTVLLPIG
LMLVKTIAELNMTKGGTLYMLLEFIGNPITAMFIAVFVAYYVLGIRQDMGMSTLLTHTEN
CFGSIANILLIIGAGGAFNAILKTSGLADTLAVILSNLDMHPILLAWLVALILHAAVGSA
TVAMMGATAIVAPMLPLYPGVSPEIIAIAIGSGAIGCTIVTDSLFWLVKQYCGASLNETF
KYYTTATFIASLLALAGTFLLSFII