Protein Info for BWI76_RS27790 in Klebsiella michiganensis M5al

Annotation: MFS transporter family glucose-6-phosphate receptor UhpC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 439 transmembrane" amino acids 27 to 45 (19 residues), see Phobius details amino acids 66 to 84 (19 residues), see Phobius details amino acids 96 to 114 (19 residues), see Phobius details amino acids 119 to 143 (25 residues), see Phobius details amino acids 156 to 179 (24 residues), see Phobius details amino acids 185 to 203 (19 residues), see Phobius details amino acids 246 to 268 (23 residues), see Phobius details amino acids 287 to 309 (23 residues), see Phobius details amino acids 321 to 339 (19 residues), see Phobius details amino acids 345 to 366 (22 residues), see Phobius details amino acids 377 to 400 (24 residues), see Phobius details amino acids 407 to 431 (25 residues), see Phobius details PF07690: MFS_1" amino acids 35 to 396 (362 residues), 181.1 bits, see alignment E=1.5e-57 TIGR00881: phosphoglycerate transporter family protein" amino acids 36 to 413 (378 residues), 498.8 bits, see alignment E=5e-154

Best Hits

Swiss-Prot: 90% identical to UHPC_ECOLI: Membrane sensor protein UhpC (uhpC) from Escherichia coli (strain K12)

KEGG orthology group: K07783, MFS transporter, OPA family, sugar phosphate sensor protein UhpC (inferred from 94% identity to kpu:KP1_5445)

Predicted SEED Role

"Hexose phosphate uptake regulatory protein UhpC" in subsystem Hexose Phosphate Uptake System

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AV78 at UniProt or InterPro

Protein Sequence (439 amino acids)

>BWI76_RS27790 MFS transporter family glucose-6-phosphate receptor UhpC (Klebsiella michiganensis M5al)
MFAFLKSPPDAPPITDKQALDERYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILASN
VLTRSDIGLLATLFYITYGLSKFFSGIVSDRSNARYFMGIGLVATGVVNILFGFSTSLWA
FALLWALNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPMVVGAAALH
YGWRTGMMIAGTLAILAGLFLCWRLRDRPQAVGLPAVGDWRHDELEIAQQQEGAGLTRKE
ILTKYVLLNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVTMFEVGGF
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGGLWLMPFASYVMQAACFFTAGFFVFG
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPLAQVMEIWHWSGFFVVIAIAA
GISALLLLPFLNAQAPREA