Protein Info for BWI76_RS27625 in Klebsiella michiganensis M5al

Annotation: NADPH:quinone reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02817: zinc-binding alcohol dehydrogenase family protein
  • amino acids 12 to 335 (324 residues), 521.1 bits, E=7.3e-161
• PF08240: ADH_N
  • amino acids 32 to 88 (57 residues), 29.1 bits, E=1.1e-10
• PF00107: ADH_zinc_N
  • amino acids 159 to 265 (107 residues), 43.9 bits, E=3.4e-15
• PF13602: ADH_zinc_N_2
  • amino acids 193 to 332 (140 residues), 62 bits, E=1.9e-20

Best Hits

KEGG orthology group: None (inferred from 89% identity to eae:EAE_06665)

Predicted SEED Role

"Bifunctional protein: zinc-containing alcohol dehydrogenase; quinone oxidoreductase ( NADPH:quinone reductase) (EC 1.1.1.-); Similar to arginate lyase" (EC 1.1.1.-)

KEGG Metabolic Maps

• Alkaloid biosynthesis I
• Aminosugars metabolism
• Ascorbate and aldarate metabolism
• Benzoate degradation via CoA ligation
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of type II polyketide products
• Biosynthesis of unsaturated fatty acids
• Bisphenol A degradation
• Butanoate metabolism
• C21-Steroid hormone metabolism
• Fructose and mannose metabolism
• Glycine, serine and threonine metabolism
• Insect hormone biosynthesis
• Linoleic acid metabolism
• Nucleotide sugars metabolism
• Polyketide sugar unit biosynthesis
• Retinol metabolism
• Tetrachloroethene degradation

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.-

Use Curated BLAST to search for 1.1.1.-

Sequence Analysis Tools

See A0A285BBK2 at UniProt or InterPro

Protein Sequence (335 amino acids)

>BWI76_RS27625 NADPH:quinone reductase (Klebsiella michiganensis M5al)
MKAIAITRAATEGSNIPFLTDIELPQPVAEGHDLLVEVKAISVNPVDTKVRAGFNADTPR
VLGWDAVGVVKAVGSAVTLFAAGDEVWYAGALGRPGSNSEFQLVDERIVARKPRSLDNAS
AAALPLTTITAWELLFHRLGVEEGGNAGDTLLIVGAAGGVGSILTQLASKLTGMTVIGTA
SRAESQKWVREAGAHHVIDHSKPLADELARIGVKAVTHVASLTNTDQHYPQLIAALAPQG
KLALIDDPETLDVVPLKAKSISLHWEFMFTRSMFATPDMIAQHQLLTRVAALIDDNTIKT
TLGVHYGAITAANLQKAHAQLETGRSVGKIVLEGF