Protein Info for BWI76_RS27570 in Klebsiella michiganensis M5al

Annotation: phosphotransferase system, fructose-specific IIC component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 363 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 59 to 79 (21 residues), see Phobius details amino acids 89 to 116 (28 residues), see Phobius details amino acids 132 to 154 (23 residues), see Phobius details amino acids 176 to 196 (21 residues), see Phobius details amino acids 217 to 236 (20 residues), see Phobius details amino acids 251 to 266 (16 residues), see Phobius details amino acids 274 to 294 (21 residues), see Phobius details amino acids 308 to 334 (27 residues), see Phobius details TIGR01427: PTS system, Fru family, IIC component" amino acids 5 to 335 (331 residues), 315.1 bits, see alignment E=3.6e-98 PF02378: PTS_EIIC" amino acids 19 to 271 (253 residues), 45.9 bits, see alignment E=2.2e-16

Best Hits

KEGG orthology group: K02770, PTS system, fructose-specific IIC component (inferred from 94% identity to ecc:c4485)

Predicted SEED Role

"PTS system, fructose-specific IIBC component (EC 2.7.1.69)" (EC 2.7.1.69)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (363 amino acids)

>BWI76_RS27570 phosphotransferase system, fructose-specific IIC component (Klebsiella michiganensis M5al)
MSENKTPVSQEIKKHLLTGISWMIPLIVAAGICIALGQVLGGTNVGEKTGTIPWMLNQIG
GWGMGLIVPLICAAIAYSIADRPGFAPGLIVGFVCGQIHTGFIGGMLGGFLVGYTVLALK
HYIRLPKSMQGLMPIMVLPVLSTIISGLLMMTLIGKPIAWLQDALIHLLESMQGGSRFLL
GAILGAMATFDFGGPVNKTMSLFADGLLVSGVYGPEAVKFVGSIIPPFGITLSFLLTRHK
YTRAEREALKAAFPMGICMITEGVIPIAARDLLRVVGSCVVASAVAGGLIMTWGVESPVP
HGGMFVVPLFTHPLLFCLSLAIGTVICGVMLSLWKKPVTERDEEFDELNDQKVKDDEITF
TLE