Protein Info for BWI76_RS27565 in Klebsiella michiganensis M5al
Annotation: sugar aldolase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 35% identical to GATY_SHIBS: D-tagatose-1,6-bisphosphate aldolase subunit GatY (gatY) from Shigella boydii serotype 4 (strain Sb227)
KEGG orthology group: None (inferred from 81% identity to ecv:APECO1_2802)MetaCyc: 37% identical to tagatose-1,6-bisphosphate aldolase 2 (Escherichia coli K-12 substr. MG1655)
Tagatose-bisphosphate aldolase. [EC: 4.1.2.40]
Predicted SEED Role
"Tagatose 1,6-bisphosphate aldolase (EC 4.1.2.40)" in subsystem D-Tagatose and Galactitol Utilization or Lactose and Galactose Uptake and Utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 4.1.2.40)
MetaCyc Pathways
- superpathway of hexitol degradation (bacteria) (18/18 steps found)
- galactitol degradation (5/5 steps found)
- D-galactosamine and N-acetyl-D-galactosamine degradation (3/4 steps found)
- D-tagatose degradation (2/3 steps found)
- N-acetyl-D-galactosamine degradation (3/5 steps found)
- lactose degradation I (2/5 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.1.2.40
Use Curated BLAST to search for 4.1.2.40
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285BBZ3 at UniProt or InterPro
Protein Sequence (283 amino acids)
>BWI76_RS27565 sugar aldolase (Klebsiella michiganensis M5al) MFADMKSMVIKAWRERYALLAINCMNLESARAAVRVAEKHRAPIILNLYQGHLSHFPATT AAAVVRVLAEEASVPVTLSLDHGKDPIKIRQAFRAGFSGLMIDASAFALAENIRQTRAVA ELAASVGLCVEGELGHLADAPRYDQASNADLMTQPQDVSPFIEQTGIDLLAVSVGTAHGM YAPGVTPMLDFDRLAQIQRASSVPLALHGGSGTPFEQLQRCPEFGVAKINVGAAVFEAGK AALLHTLCHDSTIELADALSVMEQASADAIVPYLRASGSINKA