Protein Info for BWI76_RS27525 in Klebsiella michiganensis M5al

Annotation: xanthine permease XanP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 463 transmembrane" amino acids 37 to 62 (26 residues), see Phobius details amino acids 70 to 90 (21 residues), see Phobius details amino acids 128 to 147 (20 residues), see Phobius details amino acids 158 to 182 (25 residues), see Phobius details amino acids 194 to 212 (19 residues), see Phobius details amino acids 219 to 239 (21 residues), see Phobius details amino acids 259 to 280 (22 residues), see Phobius details amino acids 350 to 372 (23 residues), see Phobius details amino acids 379 to 398 (20 residues), see Phobius details amino acids 408 to 428 (21 residues), see Phobius details amino acids 439 to 458 (20 residues), see Phobius details TIGR00801: uracil-xanthine permease" amino acids 29 to 457 (429 residues), 459.4 bits, see alignment E=5.9e-142 PF00860: Xan_ur_permease" amino acids 34 to 426 (393 residues), 366 bits, see alignment E=9.8e-114

Best Hits

Swiss-Prot: 94% identical to XANP_ECO57: Xanthine permease XanP (xanP) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 98% identity to eae:EAE_06520)

MetaCyc: 94% identical to xanthine:H+ symporter XanP (Escherichia coli K-12 substr. MG1655)
RXN-5076

Predicted SEED Role

"Xanthine permease" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BBN4 at UniProt or InterPro

Protein Sequence (463 amino acids)

>BWI76_RS27525 xanthine permease XanP (Klebsiella michiganensis M5al)
MSVNTAESENAQPVAHKQTSELIYRLEDRPPLPQTLFAAFQHLLAMFVAVITPALLICQA
LGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKT
GGADVPTMMAALFGTLMLASCTEMVLSRVLHLARRIITPLVSGVVVMIIGLSLIQVGLTS
IGGGYAAMADHTFGAPKNLLLAGIVLALIIILNRQRNPYLRIASLVIAMAAGYLAAWLLD
MLPANTAPTESSLIMVPTPLYYGLGIDWNLLLPLMLVFMITSLETIGDITATSDVSEQPV
SGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLI
VLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGL
GVSQQPLILQFAPDWLKNLLSSGIAAGGITAIVLNLIFPPEKN