Protein Info for BWI76_RS26930 in Klebsiella michiganensis M5al

Annotation: biotin sulfoxide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 776 PF18364: Molybdopterin_N" amino acids 12 to 52 (41 residues), 30.8 bits, see alignment 3.4e-11 TIGR00509: molybdopterin guanine dinucleotide-containing S/N-oxide reductases" amino acids 13 to 775 (763 residues), 1094.4 bits, see alignment E=0 PF00384: Molybdopterin" amino acids 56 to 517 (462 residues), 284.2 bits, see alignment E=2.2e-88 PF01568: Molydop_binding" amino acids 636 to 749 (114 residues), 87.4 bits, see alignment E=9.9e-29

Best Hits

Swiss-Prot: 82% identical to BISC_ECOLI: Biotin sulfoxide reductase (bisC) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 92% identity to eae:EAE_06030)

MetaCyc: 82% identical to biotin sulfoxide reductase (Escherichia coli K-12 substr. MG1655)
L-methionine (S)-S-oxide reductase. [EC: 1.8.4.13]; 1.8.4.- [EC: 1.8.4.13]

Predicted SEED Role

"Anaerobic dimethyl sulfoxide reductase chain A (EC 1.8.5.3)" (EC 1.8.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.8.5.3

Use Curated BLAST to search for 1.8.4.13 or 1.8.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BB21 at UniProt or InterPro

Protein Sequence (776 amino acids)

>BWI76_RS26930 biotin sulfoxide reductase (Klebsiella michiganensis M5al)
MPTSSATKTILTAAHWGPMLVETDGENVISSRGALDTPFANSLQSAVRDQVHSKTRVRYP
MVRKGFLASPESPQGVRGQDEFVRVSWDRALDLIHTQHRRIRESYGPASIFAGSYGWRSN
GVLHKAATLLQRYMSLAGGYTGHLGDYSTGAAQAIMPYVVGGNEVYQQQTSWPMVLEHSD
VVVLWSANPLNTLKIAWNASDEQGIPWFDRLRQSGKRVICIDPMRSETAEFFGDAAEWIA
PHMGTDVALMLGIAHTLVENSWQDGPFLARCTSGYDVFARYLTGESDGTAKTAEWAAAIC
GVSADKIRELAKLFHENTTMLMSGWGMQRQQFGEQKHWMLVTLAAMLGQIGTEGGGFGLS
YHFANGGNPTRRAAVLGSMQGSVAGGTDAVEKIPVARIVEALENPGAAYQHNGMERSFPD
IRFIWWAGGANFTHHQDTNRLIRAWQKPELIVISECFWTAAARHADIVLPATTSFERNDM
TMTGDYSNQHLVPMKQVIAPRDEARDDFAVFADLSERWEAGGRERFTEGKNDLQWLETFY
QIAAQRGAQQQVTLPPFAQFWQDNQLIEMPEEPANARFARFAAFRADPQANPLKTASGKI
EIHSPTIAGYAYPDCPPHPMWLEPDEWHGNAQEGQLQVLSAHPAHRLHSQLNHTSLRERY
AVAGREPLTLHPRDAQARNIADGDLVRVWNSRGQVLAGAVVTDGIRPGVICLHEGAWPDL
DPQAGICKNGAVNVLTNDIPTSRLGNGCAGNTALAWLEKYTGPELTLTAFDPPTNA