Protein Info for BWI76_RS26900 in Klebsiella michiganensis M5al

Annotation: phosphoethanolamine transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 562 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 43 to 66 (24 residues), see Phobius details amino acids 76 to 103 (28 residues), see Phobius details amino acids 119 to 139 (21 residues), see Phobius details amino acids 160 to 178 (19 residues), see Phobius details PF08019: EptA_B_N" amino acids 60 to 169 (110 residues), 58.9 bits, see alignment E=5.6e-20 PF00884: Sulfatase" amino acids 249 to 538 (290 residues), 208.3 bits, see alignment E=1.8e-65

Best Hits

Swiss-Prot: 83% identical to EPTB_SALTY: Kdo(2)-lipid A phosphoethanolamine 7''-transferase (eptB) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: None (inferred from 91% identity to eae:EAE_06005)

MetaCyc: 82% identical to phosphoethanolamine transferase EptB (Escherichia coli K-12 substr. MG1655)
RXN-16286 [EC: 2.7.8.42]; 2.7.8.42 [EC: 2.7.8.42]; 2.7.8.42 [EC: 2.7.8.42]

Predicted SEED Role

"Phosphoethanolamine transferase specific for the outer Kdo residue of lipopolysaccharide" in subsystem Lipid A modifications

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.42

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BBJ9 at UniProt or InterPro

Protein Sequence (562 amino acids)

>BWI76_RS26900 phosphoethanolamine transferase (Klebsiella michiganensis M5al)
MKYIKTMTQLKLSIWLALYIGWFMNAAVFFRRFEGYAQEFTIWKGLSGAVELIGTFLVTF
FLLRILSLFGRRVWRILATIVVLFSAAASYYMTFLNVVIGYGIIASVMTTDIDLSREVIG
WHLILWLVLMSALPLVLIWSNRCRFTLLRQIRTPGQRMKNITIVLLAGLMVWGPIRLLEV
RQKNFERSSEVDLPSYGGVVANSYLPSNWLSALGLYAWAQVDESSDNKSLINPAKKFTYV
APQGLDDTYVVFIIGETTRWDHMGILGYNRNTTPKLAQEKNLVAFRGYSCDTATKLSLRC
MFVRQGGADDNPQRTLKEQNVFAVLHQLGFSGNLYAMQSEMWFYSNTMANNIAYREQIGA
EPSNRGKSVDDMLLVDEMKRGLAKNPSGKHLIILHTKGSHFNYTQRYPRSFAQWKPECVG
VDNKCSKAELINSYDNSVTYVDHFIVSVLDQLRDKKAIVFYAADHGESINEREHLHGTPR
KMAPPEQFRVPMLVWMSDKYLESPDHAASFARLKQQAAMKVPRRHVELYDTIMGCLGYTS
PDGGINQYNNWCHVPDAAAKKE