Protein Info for BWI76_RS26785 in Klebsiella michiganensis M5al

Annotation: UDP-forming cellulose synthase catalytic subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 872 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details transmembrane" amino acids 28 to 49 (22 residues), see Phobius details amino acids 150 to 167 (18 residues), see Phobius details amino acids 173 to 190 (18 residues), see Phobius details amino acids 197 to 216 (20 residues), see Phobius details amino acids 228 to 252 (25 residues), see Phobius details amino acids 523 to 548 (26 residues), see Phobius details amino acids 552 to 571 (20 residues), see Phobius details amino acids 639 to 659 (21 residues), see Phobius details amino acids 665 to 690 (26 residues), see Phobius details amino acids 836 to 853 (18 residues), see Phobius details TIGR03030: cellulose synthase catalytic subunit (UDP-forming)" amino acids 145 to 828 (684 residues), 997.9 bits, see alignment E=1.1e-304 PF13641: Glyco_tranf_2_3" amino acids 275 to 500 (226 residues), 57.1 bits, see alignment E=7.3e-19 PF00535: Glycos_transf_2" amino acids 277 to 446 (170 residues), 89.1 bits, see alignment E=1e-28 PF13506: Glyco_transf_21" amino acids 335 to 499 (165 residues), 26.5 bits, see alignment E=1.3e-09 PF13632: Glyco_trans_2_3" amino acids 356 to 565 (210 residues), 61.9 bits, see alignment E=2.4e-20 PF03552: Cellulose_synt" amino acids 446 to 671 (226 residues), 47 bits, see alignment E=4.6e-16 PF07238: PilZ" amino acids 694 to 790 (97 residues), 51.8 bits, see alignment E=2.6e-17

Best Hits

Swiss-Prot: 84% identical to BCSA_SALTY: Cellulose synthase catalytic subunit [UDP-forming] (bcsA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: None (inferred from 95% identity to eae:EAE_05925)

MetaCyc: 84% identical to cellulose synthase catalytic subunit (Escherichia coli K-12 substr. MG1655)
Cellulose synthase (UDP-forming). [EC: 2.4.1.12]

Predicted SEED Role

"Cellulose synthase catalytic subunit [UDP-forming] (EC 2.4.1.12)" (EC 2.4.1.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.12

Use Curated BLAST to search for 2.4.1.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BB40 at UniProt or InterPro

Protein Sequence (872 amino acids)

>BWI76_RS26785 UDP-forming cellulose synthase catalytic subunit (Klebsiella michiganensis M5al)
MIRLSALLLAPPVGKRLSERYLDYRQHGASWLSAALGCLWASLAWAFMPLETPRWQAIRE
RHGEFFPHINPHRPRPLDPIRYLLQAVWLLATRVPEPDKKINWRSLAALEGVQGRYAQWL
EKLPEKVNARTGHLDKHKELGHLNPKIRRLILGAITFFSLILALLCITQPFNPLSQFIFL
LLLWGVALLVRRIPGRFSALMLIVLSLTVSCRYIWWRYTSTLNWDDPVSLVCGIILLFAE
TYAWVVLVLGYFQVVWPLNRQPVPLPEDMAQWPTVDIFVPTYNEDLNVVKNTIYASQGID
WPKDKLNIWILDDGGREEFRQFAKDVGVHYIARTTHEHAKAGNINNALKYAKGEFVSIFD
CDHVPTRSFLQMTMGWFLKEKKLAMMQTPHHFFSPDPFERNLGRFRKTPNEGTLFYGLVQ
DGNDMWDATFFCGSCAVIRRGPLDEIGGIAVETVTEDAHTSLRLHRRGHTSAYMRIPQAA
GLATESLSAHIGQRIRWARGMVQIFRLDNPLFGKGLKLAQRVCYVNAMLHFLSGIPRLIF
LTAPLAFLLLHAYIIYAPALMIALFVLPHMIHASLTNSKIQGKYRHSFWSEIYETVLAWY
IAPPTFVALINPHKGKFNVTAKGGLVEDEYVDWVISRPYIYLVLLNLVGVGVGIWRFIYG
PENEILTVWVSIIWVFYNLIILGGAVAVSVESKQVRRSHRVEMSMPAAIAREDGHLFSCT
VHDYSDGGLGVKIHGEAQVLESQHVKLLLKRGQQEYAFPVRVARVNGSEVGLQLLPLSNQ
QHIDFVQCTFARADTWALWQDSFPEDKPMESLLDILKLGFRGYRHLAEFSPPSVKGIFRS
LTMLVAWFVSFIPRRPERAAATLSAEPAMAQQ