Protein Info for BWI76_RS26485 in Klebsiella michiganensis M5al

Annotation: UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 379 PF01041: DegT_DnrJ_EryC1" amino acids 12 to 373 (362 residues), 442.9 bits, see alignment E=1.5e-136 PF01053: Cys_Met_Meta_PP" amino acids 32 to 166 (135 residues), 34.4 bits, see alignment E=1.4e-12 PF00155: Aminotran_1_2" amino acids 35 to 163 (129 residues), 33.9 bits, see alignment E=3e-12

Best Hits

Swiss-Prot: 93% identical to ARNB_KLEP3: UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (arnB) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: None (inferred from 94% identity to eae:EAE_05700)

MetaCyc: 78% identical to UDP-4-amino-4-deoxy-L-arabinose aminotransferase (Escherichia coli K-12 substr. MG1655)
RXN0-1863 [EC: 2.6.1.87, 2.6.1.92]

Predicted SEED Role

"UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (EC 2.6.1.-)" in subsystem Lipid A-Ara4N pathway ( Polymyxin resistance ) (EC 2.6.1.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.-

Use Curated BLAST to search for 2.6.1.- or 2.6.1.87 or 2.6.1.92

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BBB9 at UniProt or InterPro

Protein Sequence (379 amino acids)

>BWI76_RS26485 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (Klebsiella michiganensis M5al)
MSDFLPFSRPSMGDAELAALREVLQSGWITTGPKNQALEEAFCTLTGNRHAIAVSSATGG
MHVTLMALGIGAGDEVITPSQTWVSTLNMICLLGATPVMIDVDPDNLMITPEAVEAAITP
RTKAIIPVHYAGAPADIDAIRAIGERHAIPVIEDAAHAAGTYYKGRHVGWRGTAIFSFHA
IKNMTCAEGGLVVTDDDELAARIRSLKFHGLGVDAYDRQTLGRAPQAEVISPGFKYNLAD
INAALALVQLDKLAHANQRRAAIAQRYLRELADTPFRPLVAPSWEHQHAWHLFIIRVDEA
ACGISRDALMEKLKAMGIGTGLHFRAAHTQKYYRERFPEVSLPHTEWNSARICSIPLFPD
MTDDDVTRVISALHQLSGR