Protein Info for BWI76_RS26480 in Klebsiella michiganensis M5al

Annotation: undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 327 transmembrane" amino acids 235 to 261 (27 residues), see Phobius details amino acids 269 to 294 (26 residues), see Phobius details PF13641: Glyco_tranf_2_3" amino acids 9 to 156 (148 residues), 48.3 bits, see alignment E=1.8e-16 PF00535: Glycos_transf_2" amino acids 11 to 172 (162 residues), 118.6 bits, see alignment E=4.3e-38 PF10111: Glyco_tranf_2_2" amino acids 11 to 103 (93 residues), 28.1 bits, see alignment E=2.2e-10

Best Hits

Swiss-Prot: 96% identical to ARNC_KLEP3: Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (arnC) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: K10012, undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [EC: 2.7.8.30] (inferred from 95% identity to kpu:KP1_5184)

MetaCyc: 85% identical to undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (Escherichia coli K-12 substr. MG1655)
RXN0-3521 [EC: 2.4.2.53]

Predicted SEED Role

"Polymyxin resistance protein ArnC, glycosyl transferase (EC 2.4.-.-)" in subsystem Lipid A-Ara4N pathway ( Polymyxin resistance ) (EC 2.4.-.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.-.-

Use Curated BLAST to search for 2.4.-.- or 2.4.2.53 or 2.7.8.30

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BB73 at UniProt or InterPro

Protein Sequence (327 amino acids)

>BWI76_RS26480 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (Klebsiella michiganensis M5al)
MFSYPPVKKVSVVIPVYNEQESLPELIRRTDTACATLGRQYEILLVDDGSSDDSARMLTE
AAEAEGSHVVAVLLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVEKADEG
YDVVGTVRQNRQDTFFRKSASKMINRLIQRTTGKAMGDYGCMLRAYRRHIIDAMLNCHER
STFIPILANTFARRAVEIPVMHAEREFGDSKYSFMRLINLMYDLVTCLTTTPLRLLSLFG
SAIALLGFAFGLMLVVLRLVFGPQWAAEGVFMLFAVLFMFIGAQFVGMGLLGEYIGRIYN
DVRARPRYFIQRVVRQPETASQEEDRS