Protein Info for BWI76_RS25990 in Klebsiella michiganensis M5al

Annotation: cAMP-activated global transcriptional regulator CRP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 210 PF00027: cNMP_binding" amino acids 22 to 108 (87 residues), 86.7 bits, see alignment E=1.3e-28 PF13545: HTH_Crp_2" amino acids 142 to 206 (65 residues), 50.4 bits, see alignment E=2.7e-17 PF00325: Crp" amino acids 166 to 197 (32 residues), 37.5 bits, see alignment 2.3e-13

Best Hits

Swiss-Prot: 100% identical to CRP_SALTY: cAMP-activated global transcriptional regulator CRP (crp) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K10914, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein (inferred from 100% identity to etw:ECSP_4315)

Predicted SEED Role

"Cyclic AMP receptor protein" in subsystem CytR regulation or cAMP signaling in bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BAM6 at UniProt or InterPro

Protein Sequence (210 amino acids)

>BWI76_RS25990 cAMP-activated global transcriptional regulator CRP (Klebsiella michiganensis M5al)
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEM
ILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQ
MARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCS
RETVGRILKMLEDQNLISAHGKTIVVYGTR