Protein Info for BWI76_RS25585 in Klebsiella michiganensis M5al

Annotation: multidrug efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1036 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 395 to 415 (21 residues), see Phobius details amino acids 438 to 459 (22 residues), see Phobius details amino acids 470 to 497 (28 residues), see Phobius details amino acids 539 to 557 (19 residues), see Phobius details amino acids 872 to 890 (19 residues), see Phobius details amino acids 897 to 917 (21 residues), see Phobius details amino acids 923 to 946 (24 residues), see Phobius details amino acids 973 to 993 (21 residues), see Phobius details amino acids 1005 to 1027 (23 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1034 (1034 residues), 1844.2 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1028 (1028 residues), 1434.9 bits, see alignment E=0 PF03176: MMPL" amino acids 330 to 513 (184 residues), 24.7 bits, see alignment E=1.6e-09

Best Hits

Swiss-Prot: 86% identical to ACRF_ECOLI: Multidrug export protein AcrF (acrF) from Escherichia coli (strain K12)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 69% identity to abo:ABO_0964)

MetaCyc: 81% identical to multidrug efflux pump RND permease AcrB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-356; TRANS-RXN-357; TRANS-RXN-359; TRANS-RXN0-592

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BAU1 at UniProt or InterPro

Protein Sequence (1036 amino acids)

>BWI76_RS25585 multidrug efflux RND transporter permease subunit (Klebsiella michiganensis M5al)
MSKFFIHRPVFAWVLAIIMMIAGGLAIMQLPIAQYPTIAPPAVAISATYPGADAQTVQDT
VTQVIEQNMNGIDNLMYMSSTSDSAGGVTITLTFTSGTDPDIAQVQVQNKLQLATPLLPQ
EVQQQGISVEKSSSSFLMVAGFISDNASTTQDDISDYVASNVKDTISRLNGVGDVQLFGA
QYAMRVWLDGNLLNKYNLTPVDVINQLQIQNDQIAAGQLGGTPALKGQQLNASIIAQTRL
KDPAEFGKVTLRVNADGSVVHLKDVARIELGGENYNVVAKINGKPASGLGIKLATGANAL
DTAAAIKAKLAELQPYFPQGMKVVYPYDTTPFVKISIHEVVKTLFEAIILVFLVMYLFLQ
NIRATLIPTIAVPVVLLGTFAVLATFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVM
VEEKLPPKEATEKSMAQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL
SVLVALILTPALCATLLKPASADHHEKKGFFGWFNAKFDRSVSHYTNSVSGILRCTGRYL
IIYLLIVVGMAVLFVRLPTSFLPDEDQGVFMTMIQLPSGATQERTQKVLDTVTDYYLHKE
KANVESVFTVNGFSFSGQGQNSGMAFVSLKPWEERSGSENGVEAIIKRATAAFSQIKDAM
VFPFNLPAIIELGTATGFDFELIDQGNLGHSALTQARNQLLGMVREHPDQLVRVRPNGLE
DTPQFKLDVDQEKAQALGISLSDINETISAALGGYYVNDFIDHGRVKKVYVQADAKFRML
PSDINNMYVRSANGEMVPFSAFVTSRWVYGSPRLERYNGLPSMEMLGEAAPGKSTGDAMI
LMEQLASKLPTGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVM
LVVPLGVVGALLAASLRGLNNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGIIE
ATLEASRMRLRPILMTSLAFILGVLPLVISHGAGSGAQNAVGTGVMGGMLMATLLAIFFV
PVFFVVVRRRFTKHAE