Protein Info for BWI76_RS25555 in Klebsiella michiganensis M5al

Annotation: 50S ribosomal protein L11 methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 293 PF06325: PrmA" amino acids 2 to 292 (291 residues), 364.5 bits, see alignment E=1.9e-112 TIGR00406: ribosomal protein L11 methyltransferase" amino acids 3 to 286 (284 residues), 407.3 bits, see alignment E=1.9e-126 PF01135: PCMT" amino acids 144 to 207 (64 residues), 20.9 bits, see alignment E=1.1e-07 PF05175: MTS" amino acids 145 to 230 (86 residues), 37.3 bits, see alignment E=8.7e-13 PF13489: Methyltransf_23" amino acids 156 to 230 (75 residues), 29.6 bits, see alignment E=2.1e-10 PF13847: Methyltransf_31" amino acids 159 to 230 (72 residues), 39.8 bits, see alignment E=1.5e-13 PF13649: Methyltransf_25" amino acids 162 to 229 (68 residues), 33.1 bits, see alignment E=3e-11 PF08242: Methyltransf_12" amino acids 163 to 231 (69 residues), 30.9 bits, see alignment E=1.5e-10 PF08241: Methyltransf_11" amino acids 164 to 211 (48 residues), 25.8 bits, see alignment 5.6e-09

Best Hits

Swiss-Prot: 94% identical to PRMA_SALEP: Ribosomal protein L11 methyltransferase (prmA) from Salmonella enteritidis PT4 (strain P125109)

KEGG orthology group: K02687, ribosomal protein L11 methyltransferase [EC: 2.1.1.-] (inferred from 92% identity to ecv:APECO1_3179)

MetaCyc: 92% identical to ribosomal protein L11 methyltransferase (Escherichia coli K-12 substr. MG1655)
RXN0-5419

Predicted SEED Role

"Ribosomal protein L11 methyltransferase (EC 2.1.1.-)" in subsystem Heat shock dnaK gene cluster extended or Ribosome biogenesis bacterial (EC 2.1.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.-

Use Curated BLAST to search for 2.1.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BAM4 at UniProt or InterPro

Protein Sequence (293 amino acids)

>BWI76_RS25555 50S ribosomal protein L11 methyltransferase (Klebsiella michiganensis M5al)
MPWIQLKLNTTGANAEELSDALMEAGSVSITFQDTHDTPVFEPLPGETRLWGDTDVIGLF
DAETDMEEVVAILQQHPLLGVGFVHKIEQLEDKDWEREWMDNFHPMCFGQRLWICPSWRD
VPDENAVNVMLDPGLAFGTGTHPTTAMCLQWLDGLDLAGKTIIDFGCGSGILAIAALKLG
AAKAIGIDIDPQAIQASRDNAERNGVSERLELYLPKDQPEAMKADVVVANILAGPLRELA
PLISVLPVTGGLLGLSGILASQAESVCEAYAELFELDPVVEKEEWCRITGYKK