Protein Info for BWI76_RS25470 in Klebsiella michiganensis M5al

Annotation: metalloprotease TldD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 481 PF01523: PmbA_TldD_1st" amino acids 37 to 98 (62 residues), 48.5 bits, see alignment E=1.2e-16 PF19290: PmbA_TldD_2nd" amino acids 125 to 238 (114 residues), 78.8 bits, see alignment E=6.8e-26 PF19289: PmbA_TldD_3rd" amino acids 246 to 479 (234 residues), 217.3 bits, see alignment E=2.3e-68

Best Hits

Swiss-Prot: 92% identical to TLDD_SHIFL: Metalloprotease TldD homolog (tldD) from Shigella flexneri

KEGG orthology group: None (inferred from 97% identity to eae:EAE_04635)

MetaCyc: 92% identical to metalloprotease subunit TldD (Escherichia coli)
3.4.24.-

Predicted SEED Role

"TldD protein, part of TldE/TldD proteolytic complex"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BAC4 at UniProt or InterPro

Protein Sequence (481 amino acids)

>BWI76_RS25470 metalloprotease TldD (Klebsiella michiganensis M5al)
MSLNLVSEQLLSANGLNHQDLFTILGQLAERRLDYGDLYFQSSYHESWVLEDSIIKDGSY
NIDQGVGVRAVSGEKTGFAYADQISRLALEQSAQAARTIVRDHGDGKVHTLGGVEYSSLY
TSIDPLQSMSREEKLDILRRVDKTARAADKRVQEVSASLTGVYELILVAATDGTLAADVR
PLVRLSVSVLVEEDGKRERGASGGGGRFGYDYFLASQDGDVRADVWAREAVRMALVNLTA
VAAPAGMLPVVLGAGWPGVLLHEAVGHGLEGDFNRRGTSVFSGHMGELVASELCTVVDDG
TIANRRGSVAIDDEGTPGQYNVLIENGILKGYMQDKLNARLMGVAPTGNGRRESYAHLPM
PRMTNTYMLAGKSTPQEIIESVDYGIYAPNFGGGQVDITSGKFVFSTSEAYLIEKGKVTK
AVKGATLIGSGIEAMQQISMVGNDLKLDSGVGVCGKEGQSVPVGVGQPTLKVDKLTVGGT
A