Protein Info for BWI76_RS25385 in Klebsiella michiganensis M5al

Annotation: oxaloacetate decarboxylase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 588 PF00682: HMGL-like" amino acids 3 to 268 (266 residues), 229.9 bits, see alignment E=1e-71 TIGR01108: oxaloacetate decarboxylase alpha subunit" amino acids 5 to 584 (580 residues), 990 bits, see alignment E=1.8e-302 PF02436: PYC_OADA" amino acids 290 to 488 (199 residues), 193.1 bits, see alignment E=1.2e-60 PF13533: Biotin_lipoyl_2" amino acids 521 to 564 (44 residues), 26.3 bits, see alignment 1.2e-09 PF00364: Biotin_lipoyl" amino acids 522 to 587 (66 residues), 64.9 bits, see alignment E=1.2e-21

Best Hits

Swiss-Prot: 93% identical to DCOA_SALTY: Oxaloacetate decarboxylase alpha chain (oadA1) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01571, oxaloacetate decarboxylase, alpha subunit [EC: 4.1.1.3] (inferred from 95% identity to sea:SeAg_B0062)

Predicted SEED Role

"Oxaloacetate decarboxylase alpha chain (EC 4.1.1.3)" in subsystem Na+ translocating decarboxylases and related biotin-dependent enzymes or Pyruvate metabolism I: anaplerotic reactions, PEP (EC 4.1.1.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.3

Use Curated BLAST to search for 4.1.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (588 amino acids)

>BWI76_RS25385 oxaloacetate decarboxylase subunit alpha (Klebsiella michiganensis M5al)
MTVAITDVVLRDAHQSLFATRLRLDDMLPVAAQLDDVGYGSLECWGGATFDACIRFLGED
PWVRLRELKKAMPKTPLQMLLRGQNLLGYRHYADDVVEHFVERAVKNGMDVFRVFDAMND
PRNMQAALRAVRSHGAHAQGTLSYTTSPAHTLQTWLDLTEQLLETGVDSIAIKDMSGILT
PMAAYELVSEIKKRYDVRLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSATYGHPA
TEALVATLAGTEHDTGLDILKLESIAAYFREVRRKYHAFEGQLKGTDSRILVAQVPGGML
TNLEGQLKQQNAAHRLDEVLAEIPRVREDLGFIPLVTPTSQIVGTQAVLNVLTGERYKTI
AKETAGILKGEYGHTPVPVNAALQARVLEGAAPVTCRPADLLKPELAALEADVKRQAQEK
GITLADNAIDDVLTVALFPQIGLKFLENRNNPAAFEPVPQAEEAKPAAAPVKPAASGIYT
VEVEGQAFAVKVSDGGDISQLTAAVPATAPAAAAPAGAGTPVTAPLAGNIWKVTATEGQT
VAEGDVLLILEAMKMETEIRAAQAGTVRGIAVKSGDAVAVGDTLMTLA