Protein Info for BWI76_RS25215 in Klebsiella michiganensis M5al

Annotation: phospholipid-binding protein MlaC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 211 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF05494: MlaC" amino acids 33 to 198 (166 residues), 175.9 bits, see alignment E=3.1e-56

Best Hits

Swiss-Prot: 90% identical to MLAC_ECOLI: Intermembrane phospholipid transport system binding protein MlaC (mlaC) from Escherichia coli (strain K12)

KEGG orthology group: K07323, putative toluene tolerance protein (inferred from 97% identity to kpn:KPN_03602)

Predicted SEED Role

"Uncharacterized ABC transporter, auxiliary component YrbC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BA74 at UniProt or InterPro

Protein Sequence (211 amino acids)

>BWI76_RS25215 phospholipid-binding protein MlaC (Klebsiella michiganensis M5al)
MFKRLLMVAMLVIAPLTAATAADQSNPYKLMDEAAQKTFDRLKNEQPKIQANPNYLRDIV
DQELLPYVQVKYAGALVLGRYYKEATPAQREAYFAAFREYLKQAYGQALAMYHGQTYQIA
PEQPLGSATIVPIRVTILDPNGRPPVRLDFQWRKNTQTGNWQAYDMIAEGVSMITTKQNE
WSDLLRTKGVDGLTAQLKASSAQPITLEQKK