Protein Info for BWI76_RS25130 in Klebsiella michiganensis M5al

Annotation: phosphoglucosamine mutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 4 to 136 (133 residues), 156.1 bits, E=8.9e-50
• TIGR01455: phosphoglucosamine mutase
  • amino acids 7 to 443 (437 residues), 656 bits, E=1.2e-201
• PF02879: PGM_PMM_II
  • amino acids 157 to 254 (98 residues), 72.4 bits, E=8.4e-24
• PF02880: PGM_PMM_III
  • amino acids 258 to 366 (109 residues), 119 bits, E=2.4e-38
• PF00408: PGM_PMM_IV
  • amino acids 373 to 443 (71 residues), 69.9 bits, E=3.1e-23

Best Hits

Swiss-Prot: 98% identical to GLMM_KLEP7: Phosphoglucosamine mutase (glmM) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K03431, phosphoglucosamine mutase [EC: 5.4.2.10] (inferred from 97% identity to kpu:KP1_4895)

MetaCyc: 92% identical to phosphoglucosamine mutase (Escherichia coli K-12 substr. MG1655)
Phosphoglucosamine mutase. [EC: 5.4.2.10]

Predicted SEED Role

"Phosphoglucosamine mutase (EC 5.4.2.10)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 5.4.2.10)

MetaCyc Pathways

• superpathway of anaerobic sucrose degradation (18/19 steps found)
• peptidoglycan recycling I (14/14 steps found)
• O-antigen building blocks biosynthesis (E. coli) (11/11 steps found)
• glycogen degradation I (8/8 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• glucose and glucose-1-phosphate degradation (5/5 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (4/4 steps found)
• starch degradation III (4/4 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• D-galactose degradation I (Leloir pathway) (4/5 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• sucrose biosynthesis II (6/8 steps found)
• starch degradation V (3/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• glycogen degradation II (4/6 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• chitin biosynthesis (6/9 steps found)
• glucosylglycerol biosynthesis (3/5 steps found)
• starch biosynthesis (6/10 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (4/8 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (1/5 steps found)
• colanic acid building blocks biosynthesis (5/11 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (9/19 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (13/33 steps found)
• streptomycin biosynthesis (2/18 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.2.10

Sequence Analysis Tools

See A0A285BA13 at UniProt or InterPro

Protein Sequence (445 amino acids)

>BWI76_RS25130 phosphoglucosamine mutase (Klebsiella michiganensis M5al)
MSNRKYFGTDGIRGRVGDAPITPEFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLES
ALEAGLAAAGLSASFTGPMPTPAIAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIEGTK
LPDEVEEAIEAEMEKELTCVDSAELGKASRIVDAAGRYIEFCKGTFPNELSLNSLKVVVD
CAHGATYHIAPNVFRELGAQVIAMGCEPDGLNINEEVGATDVRALQARVLAEKADLGIAY
DGDGDRVIMVDHEGNKVDGDQILYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIP
FVRAKVGDRYVLEKLQEKGWRIGAENSGHVILLDKTTTGDGIVASLQVVAAMVRNHLSLH
DLCSGMKMFPQLLVNVRFTEGSGNPLEHEHVKAVTAEVEAALGNRGRVLLRKSGTEPLIR
VMVEGEHEEQVHEFAHRIADAVKSV