Protein Info for BWI76_RS24875 in Klebsiella michiganensis M5al

Annotation: tagatose-1,6-bisphosphate aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08013: GatZ_KbaZ-like
  • amino acids 1 to 418 (418 residues), 651.8 bits, E=2e-200
• TIGR02810: D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit
  • amino acids 3 to 418 (416 residues), 678.7 bits, E=1.6e-208

Best Hits

Swiss-Prot: 98% identical to GATZ_KLEOX: D-tagatose-1,6-bisphosphate aldolase subunit GatZ (gatZ) from Klebsiella oxytoca

KEGG orthology group: K00917, tagatose 6-phosphate kinase [EC: 2.7.1.144] (inferred from 94% identity to kpu:KP1_4851)

MetaCyc: 72% identical to putative tagatose-1,6-bisphosphate aldolase 2 chaperone (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Tagatose-6-phosphate kinase GatZ (EC 2.7.1.144)" in subsystem D-Tagatose and Galactitol Utilization (EC 2.7.1.144)

MetaCyc Pathways

• superpathway of hexitol degradation (bacteria) (18/18 steps found)
• galactitol degradation (5/5 steps found)
• D-galactosamine and N-acetyl-D-galactosamine degradation (3/4 steps found)
• N-acetyl-D-galactosamine degradation (3/5 steps found)
• lactose degradation I (2/5 steps found)

KEGG Metabolic Maps

• Galactose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.144

Sequence Analysis Tools

See A0A285BA93 at UniProt or InterPro

Protein Sequence (423 amino acids)

>BWI76_RS24875 tagatose-1,6-bisphosphate aldolase (Klebsiella michiganensis M5al)
MKDIISRHKAGEHIGICSVCSAHPLVIEAALRFDLHTNNKVLIEATSNQVNQFGGYTGMQ
PADFRDFVNKIAREVGFPSERIILGGDHLGPNCWQGEPAAEAMEKSVDLIKAYVAAGFSK
IHLDASMSCADDPVPLDPAIVAERAARLCQAAEETATDEQKRHLTYVIGTEVPVPGGEAS
TIGSVHVTRAQDAAATLETHEAAFRKLGLNAALERVIAIVVQPGVEFDHTQIIHYQPEAA
KALSAWIEGTPMVYEAHSTDYQSRQAYRALVRDHYAILKVGPALTFALREAIFALAQMEN
ELVAPESRSRVMEVIDEVMLNEPGYWKKYYRPTWSQAMVDIHFSLSDRIRYYWPHPRIRQ
SVEKLIANLTETKLPLGLISQYMPVQFERLSLNELAAVPHDLILDKIQDVLRAYRYGCSS
EIA