Protein Info for BWI76_RS24650 in Klebsiella michiganensis M5al

Annotation: putative transport system permease component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 330 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 23 to 23 (1 residues), see Phobius details amino acids 32 to 55 (24 residues), see Phobius details amino acids 61 to 81 (21 residues), see Phobius details amino acids 86 to 108 (23 residues), see Phobius details amino acids 115 to 139 (25 residues), see Phobius details amino acids 153 to 179 (27 residues), see Phobius details amino acids 210 to 232 (23 residues), see Phobius details amino acids 247 to 277 (31 residues), see Phobius details amino acids 289 to 310 (22 residues), see Phobius details PF02653: BPD_transp_2" amino acids 33 to 303 (271 residues), 156.6 bits, see alignment E=3.7e-50

Best Hits

Swiss-Prot: 94% identical to LSRD_KLEP7: Autoinducer 2 import system permease protein LsrD (lsrD) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K10557, AI-2 transport system permease protein (inferred from 93% identity to kva:Kvar_0595)

MetaCyc: 72% identical to Autoinducer-2 ABC transporter membrane subunit LsrD (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-454 [EC: 7.6.2.13]

Predicted SEED Role

"Autoinducer 2 (AI-2) ABC transport system, membrane channel protein LsrD" in subsystem Autoinducer 2 (AI-2) transport and processing (lsrACDBFGE operon)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285BA39 at UniProt or InterPro

Protein Sequence (330 amino acids)

>BWI76_RS24650 putative transport system permease component (Klebsiella michiganensis M5al)
MKLSWESALLALLVLEILLFGALNPRMLDLNMLLFSTSDFICIGIVALPLTLVIISGGID
ISLGSTIGLCAIALGVMMQAGWPMSLAIPLTLLLGLLCGLLNAALIHYTGISPLVITLGT
LYLYGGGALLLSGMAGATGYEGIGGFPDSFTAFANLTLFGLPIPLVLFAVITFFFWLLAH
RGRFGRHLFLLGQNPRAARYAALSVNGMPYALYGLVGVASAVAALVMVSYFGSARSDLGR
DLLMPALTAAVLGGANIYGGSGSIVGTALAALLVGYLQQGLQMVGIPNQVSSALSGALLV
VVVMGRSLSLHREWVRMSWRRLFSRKTIGA