Protein Info for BWI76_RS24465 in Klebsiella michiganensis M5al

Annotation: adenylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01928: CYTH
  • amino acids 3 to 196 (194 residues), 113.5 bits, E=5.4e-37

Best Hits

Swiss-Prot: 64% identical to 3PASE_ECOLI: Inorganic triphosphatase (ygiF) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 80% identity to kva:Kvar_0637)

MetaCyc: 64% identical to inorganic triphosphatase (Escherichia coli K-12 substr. MG1655)
Triphosphatase. [EC: 3.6.1.25]

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 3.6.1.25 or 4.6.1.1

Sequence Analysis Tools

See A0A285B9V8 at UniProt or InterPro

Protein Sequence (432 amino acids)

>BWI76_RS24465 adenylate cyclase (Klebsiella michiganensis M5al)
MAQEIELKFIVAQDGVDALRQHLNTLEAKHTPAGQLLNIYYETADNWLRRHDMGLRIRGD
QGRYEMTLKIAGRVVGGLHQRPEYNIPLDTPELALEKLPAEVWPQGELPAELAQNVQPLF
STDFARERWVVKEGDSEIEIALDRGAVKAGEHQEPICELELELLSGKTQDILTLARRLLD
TGVLRQGSLSKAARGYHLAQGNEERPLTALSILRVAPKASVEQALEAALESALAHWLYHD
ELLNRGNAKAKAEILHAIARVRHALVLFGGIVPRKATTLLRERLNEAETALAEAETAQAA
LFSVATVRAKLTLTDLLVNRGWRPFLNAAGEQKIAGSFKRFADIQLSRAAAELKNAFRQP
SADGYVDQLPRLTREIDTVQLLSGAYLDVAGPWLENWQETRRAIAHNDSSVIEYFRRQAL
AAEPFWLHSGKR