Protein Info for BWI76_RS24205 in Klebsiella michiganensis M5al

Annotation: cystathionine beta-synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00291: PALP
  • amino acids 7 to 301 (295 residues), 244.1 bits, E=2.1e-76
• PF00571: CBS
  • amino acids 344 to 388 (45 residues), 37.2 bits, 2.9e-13
  • amino acids 399 to 448 (50 residues), 23.7 bits, 4.9e-09

Best Hits

KEGG orthology group: None (inferred from 92% identity to eae:EAE_18845)

Predicted SEED Role

"Cystathionine beta-synthase (EC 4.2.1.22)" in subsystem Cysteine Biosynthesis or Glycine and Serine Utilization or Methionine Biosynthesis or Methionine Degradation (EC 4.2.1.22)

MetaCyc Pathways

• homocysteine and cysteine interconversion (4/4 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (8/10 steps found)
• L-cysteine biosynthesis III (from L-homocysteine) (2/2 steps found)
• superpathway of L-cysteine biosynthesis (mammalian) (4/5 steps found)
• hydrogen sulfide biosynthesis II (mammalian) (4/6 steps found)
• superpathway of L-cysteine biosynthesis (fungi) (4/6 steps found)
• taurine biosynthesis III (1/3 steps found)
• superpathway of L-methionine salvage and degradation (10/16 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Methionine metabolism
• Selenoamino acid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.22

Sequence Analysis Tools

See A0A285B9G1 at UniProt or InterPro

Protein Sequence (456 amino acids)

>BWI76_RS24205 cystathionine beta-synthase (Klebsiella michiganensis M5al)
MSVFHSVSDLIGHTPLLQLHKLDTGPCNLFLKLENQNPGGSIKDRVALSMITQAEREGKL
KPGGTIIEATAGNTGLGLALIAAQKNYRLILVVPDKMSREKIFHLRALGAQVQLTRSDVN
KGHPAYYQDYARRLADETPGAFYIDQFNNEANPLAHATTTAPEIFQQLEGDIDAIVVGVG
SGGTLGGLQAWFAEHSPKTEFILADPAGSILADQVETGRYGETGSWLVEGIGEDFIPPLA
HLEGVRSAYRVTDSEAFATARQLLQVEGILAGSSTGTLLTAALRYCRSQTSPKRVVTFAC
DSGNKYLSKMFNDDWMRQQGFLSRPSRGDLSDFIALRHDEGATVTAAPDDTLAAILARMR
LYDISQLPVLENGRVVGIVDEWDLISHVQGDSQRFALPVREAMTRNVETLDKHAPESALK
AIFDRGLVAVIADNDRFLGLITRSDVLTTWRNRLEQ