Protein Info for BWI76_RS24055 in Klebsiella michiganensis M5al

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 464 transmembrane" amino acids 15 to 44 (30 residues), see Phobius details amino acids 56 to 77 (22 residues), see Phobius details amino acids 84 to 102 (19 residues), see Phobius details amino acids 109 to 130 (22 residues), see Phobius details amino acids 142 to 160 (19 residues), see Phobius details amino acids 172 to 192 (21 residues), see Phobius details amino acids 251 to 274 (24 residues), see Phobius details amino acids 290 to 311 (22 residues), see Phobius details amino acids 320 to 342 (23 residues), see Phobius details amino acids 348 to 373 (26 residues), see Phobius details amino acids 386 to 412 (27 residues), see Phobius details amino acids 418 to 436 (19 residues), see Phobius details TIGR00879: MFS transporter, sugar porter (SP) family" amino acids 7 to 447 (441 residues), 494.2 bits, see alignment E=2e-152 PF06609: TRI12" amino acids 10 to 198 (189 residues), 36.8 bits, see alignment E=2.7e-13 PF00083: Sugar_tr" amino acids 18 to 450 (433 residues), 472.9 bits, see alignment E=1.7e-145 PF07690: MFS_1" amino acids 23 to 283 (261 residues), 111.4 bits, see alignment E=6.9e-36 amino acids 287 to 443 (157 residues), 43.5 bits, see alignment E=3.1e-15

Best Hits

Swiss-Prot: 93% identical to GALP_ECOLI: Galactose-proton symporter (galP) from Escherichia coli (strain K12)

KEGG orthology group: K08137, MFS transporter, SP family, galactose:H+ symporter (inferred from 97% identity to kpn:KPN_03376)

MetaCyc: 93% identical to galactose:H+ symporter (Escherichia coli K-12 substr. MG1655)
RXN0-7077; TRANS-RXN-21

Predicted SEED Role

"Arabinose-proton symporter" in subsystem L-Arabinose utilization

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B9G4 at UniProt or InterPro

Protein Sequence (464 amino acids)

>BWI76_RS24055 MFS transporter (Klebsiella michiganensis M5al)
MPDNKKQGRSNKTMTFFVCFLAALAGLLFGLDIGVIAGALPFIANEFQISAHTQEWVVSS
MMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLLISRVLLGLAVG
VASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSGAWRWMLGVIIIP
AVLLLIGVVFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLKVKQSGWS
LFKENSNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYANTTEQMWGTVIVGLTN
VLATFIAIGLVDRWGRKPTLILGFIVMALGMGILGSMMHIGIHSATAQYFAVLMLLMFIV
GFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNSLGSANTFWV
YGGLNILFIFLTLWLIPETKNVSLEHIERNLMKGRKLREIGARD