Protein Info for BWI76_RS23645 in Klebsiella michiganensis M5al
Annotation: uronate isomerase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 51% identical to UXAC_STAHJ: Uronate isomerase (uxaC) from Staphylococcus haemolyticus (strain JCSC1435)
KEGG orthology group: K01812, glucuronate isomerase [EC: 5.3.1.12] (inferred from 80% identity to cko:CKO_03735)MetaCyc: 46% identical to D-glucoronate/D-galacturonate isomerase (Escherichia coli K-12 substr. MG1655)
Glucuronate isomerase. [EC: 5.3.1.12]; 5.3.1.12 [EC: 5.3.1.12]
Predicted SEED Role
"Uronate isomerase (EC 5.3.1.12)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 5.3.1.12)
MetaCyc Pathways
- superpathway of hexuronide and hexuronate degradation (9/10 steps found)
- D-galacturonate degradation I (5/5 steps found)
- superpathway of β-D-glucuronosides degradation (6/7 steps found)
- β-D-glucuronide and D-glucuronate degradation (2/3 steps found)
- pectin degradation II (3/5 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 5.3.1.12
Use Curated BLAST to search for 5.3.1.12
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285B983 at UniProt or InterPro
Protein Sequence (471 amino acids)
>BWI76_RS23645 uronate isomerase (Klebsiella michiganensis M5al) MPLINDSFMISNPTGKKLYLEIAREQPIIDYHCHLEAKAIWENEPFADITQLWLEGDHYK WRAMRANGIPEEKITGNATAEEKFAAWAQTVEACFGNPLYHWTHLELKYYFNIDDTLNSR NWHEIMTRCNEQLRRKEFLPQALIRRSNVEALCTTDGPLDNLEYHQRLAANSDFSPLVLP TFRPDELFDTDPESFQTFISRLAEKTQIRIASLQDFLAALESRIDFFHTVGCRISDHGPL EIVYNPLDEAALAALFQRRLKNEALTKDEQQAWDSAIFIALAKMYKQREWAMQIHFGAIR NNNKPMFKKVGINCGFDSVGDQTLLAGSLNALLNAMGENNGLPKTILYNLNAGYNDVVAS AIANFQSGEDGVKSPLQFGSGWWFNDTRRGMVNQLNTLADQGLLANFVGMLTDSRSFVSY TRHDYFRRILCDLIGGWVENGEVPDDKNILTSMIRDICVENARRYFRFSQA