Protein Info for BWI76_RS23625 in Klebsiella michiganensis M5al

Annotation: helix-turn-helix transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 903 PF13191: AAA_16" amino acids 45 to 186 (142 residues), 33.3 bits, see alignment E=1.1e-11 PF17874: TPR_MalT" amino acids 475 to 805 (331 residues), 83.9 bits, see alignment E=2e-27 PF00196: GerE" amino acids 842 to 894 (53 residues), 60.7 bits, see alignment 1.2e-20

Best Hits

Predicted SEED Role

"FIG00731676: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B9E9 at UniProt or InterPro

Protein Sequence (903 amino acids)

>BWI76_RS23625 helix-turn-helix transcriptional regulator (Klebsiella michiganensis M5al)
MAFLSSADDALTALVHQEPLRFTGTLPLISTRFTPPRTPESLLSRERLLLRLDAAVSRRL
TLVRAPAGFGKTTLLAQWYRHRLRQGDALAWLSLEEDDNAPLLFIRYLQEALRPLWQGWS
PSFLQLLQGELPADLPLFFAELVNQLNQCPHPLYLILDDYQCISDPAIHQGMSWLLHHAP
PALHLIIGSRSQPPLALSRLHMQDQLLEVYDPELRFSPSEARAWFAGASGLDPQAIPRLI
ALTEGWIAGMKMAALSADASAVMGLSAGSRSITRYLDEVIFAPLPPEVFDFLLQTSMLNR
LHPDLCDVVCGRNNARAMLAWIERHNLFLSALDESGLWFRYHPLMRDALLHRLRHSGEID
IRQLHDRASGWFASQQLWAEAIRHALAAGKSAAKDAEAGAQSLAEEGDIDTLVQWIRYLP
ANPDPSRIALQLNLAWALAHRFRFSEARQLLDAIEMQSAAHGEALAHSAWVKLRVVRAIC
EAFADNIDRSIAIVEPLLREVPCGDIWVDGLVCNILSYCHLADSRPQQALEVQQRVSGVS
LANRNLFVTVYRAFVMAQSYLRQGNLAEAERQAARALRYAERHAGENASSGATLAPILAE
IAWEQGKGEQAQSLLVPRLETIDSFCPPDGLSRSYIVLARQARETGRLAEAESLLLHAEG
LAAQRGWLRAQAPLLAERIAVALHAGDKQAAEALLLRLQSLSQTESVGGYITIGQSRLLI
AAGEPLAAARLLDTLAGVRESSGERLFAVRLRLRQALALWRAGERELAMAICRPALARAL
HQGLWRSLLEGREEMAALLAEIHKRGAADDALTADIAVLLSRFAAAGIVIDSARPQPLAL
RLTEREQQTLSLIADGYSNKGVARELGISAETVKWHLKQLYEKLQVKGRIQAVNQAREWR
LLG