Protein Info for BWI76_RS23170 in Klebsiella michiganensis M5al
Annotation: aldehyde dehydrogenase EutE
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K13922, propionaldehyde dehydrogenase (inferred from 98% identity to sew:SeSA_A2221)MetaCyc: 98% identical to CoA-dependent propanal dehydrogenase (Salmonella enterica enterica serovar Typhimurium str. LT2)
RXN-12736 [EC: 1.2.1.87]; 1.2.1.87 [EC: 1.2.1.87]; 1.2.1.87 [EC: 1.2.1.87]
Predicted SEED Role
"CoA-acylating propionaldehyde dehydrogenase" in subsystem Propanediol utilization
MetaCyc Pathways
- (S)-propane-1,2-diol degradation (5/5 steps found)
- 1,2-propanediol biosynthesis from lactate (engineered) (4/6 steps found)
- androstenedione degradation I (aerobic) (7/25 steps found)
- superpathway of testosterone and androsterone degradation (7/28 steps found)
- superpathway of cholesterol degradation I (cholesterol oxidase) (9/42 steps found)
- superpathway of cholesterol degradation II (cholesterol dehydrogenase) (9/47 steps found)
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.87
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285B8B3 at UniProt or InterPro
Protein Sequence (463 amino acids)
>BWI76_RS23170 aldehyde dehydrogenase EutE (Klebsiella michiganensis M5al) MNTSELETLIRTILSEQLTPAQTPEQPQGKGIFQSVSEAIDAAHQAFLRYQQCPLKTRSA IISAMRQELTPLLAALAEESANETGMGNKEDKYLKNKAALDNTPGVEDLTTTALTGDGGM VLFEYSPFGVIGSVAPSTNPTETIINNSISMLAAGNSVYFSPHPGAKKVSLKLISLIEEI AFRCCGIRNLVVTVAEPTFEATQQMMAHPRIAVLAITGGPGIVAMGMKSGKKVIGAGAGN PPCIVDETADLVKAAEDIINGASFDYNLPCIAEKSLIVVESVAERLVQQMQAFGALLLSP ADTDKLRAACLPEGLANKKLVGKSPSAMLEAAGIAVPAKAPRLLIAIVNADDPWVTSEQL MPMLPVVKVSDFDSALALALKVEEGLHHTAIMHSQNVSRLNLAARTLQTSIFVKNGPSYA GIGVGGEGFTTFTIATPTGEGTTSARTFARSRRCVLTNGFSIR