Protein Info for BWI76_RS22925 in Klebsiella michiganensis M5al

Annotation: L-fucose isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01089: L-fucose isomerase
  • amino acids 5 to 590 (586 residues), 1214.4 bits, E=0
• PF07881: Fucose_iso_N1
  • amino acids 7 to 174 (168 residues), 275.6 bits, E=2.2e-86
• PF07882: Fucose_iso_N2
  • amino acids 175 to 354 (180 residues), 277.9 bits, E=4.7e-87
• PF02952: Fucose_iso_C
  • amino acids 390 to 554 (165 residues), 161.7 bits, E=1.4e-51

Best Hits

Swiss-Prot: 96% identical to FUCI_CITK8: L-fucose isomerase (fucI) from Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

KEGG orthology group: K01818, L-fucose isomerase [EC: 5.3.1.25] (inferred from 96% identity to cko:CKO_04161)

MetaCyc: 93% identical to L-fucose isomerase (Escherichia coli K-12 substr. MG1655)
Arabinose isomerase. [EC: 5.3.1.3]; L-fucose isomerase. [EC: 5.3.1.3, 5.3.1.25]

Predicted SEED Role

"L-fucose isomerase (EC 5.3.1.25)" in subsystem L-fucose utilization (EC 5.3.1.25)

MetaCyc Pathways

• superpathway of fucose and rhamnose degradation (11/12 steps found)
• D-arabinose degradation II (4/4 steps found)
• L-fucose degradation I (4/4 steps found)
• D-arabinose degradation I (2/2 steps found)
• superpathway of pentose and pentitol degradation (21/42 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.25 or 5.3.1.3

Sequence Analysis Tools

See A0A285AXU3 at UniProt or InterPro

Protein Sequence (591 amino acids)

>BWI76_RS22925 L-fucose isomerase (Klebsiella michiganensis M5al)
MKKISLPKIGIRPVIDGRRMGVRESLEEQTMNMAKATAALIAEKLRHACGAQIECVIADS
CIAGMAESAACEEKFSSQNVGVTITVTPCWCYGSETIDMDPLRPKAIWGFNGTERPGAVY
LAAALAAHSQKGIPAFSIYGHDVQDADDTTIPPDVEEKLLRFARAGLAVASMKGKSYLSV
GGVSMGIAGSIVDHNFFESWLGMKVQAVDMTELRRRIDQKIYDESELEMALAWADKNFRY
GEDQNAQQYKRNAEQSRAVLKESLLMAMCIRDMMQGNSKLAEKGLVEESLGYNAIAAGFQ
GQRHWTDQYPNGDTAEALLNSSFDWNGVREPFVVATENDSLNGVAMLMGHQLTGTAQVFA
DVRTYWSPEAVERVTGQPLTGLAEHGIIHLINSGSAALDGACKQRDADGKPTMKPHWEIS
QQEADACLAATEWCPAIHEYFRGGGFSSRFLTEGGVPFTMTRVNIIKGLGPVLQIAEGWS
VELPKAMHDQLDARTNSTWPTTWFAPRLTGKGPFSDVYSVMANWGANHGVLTIGHVGADF
ITLASMLRIPVCMHNVEEAKIYRPSSWSAHGMDSEGQDYRACQNYGPLYKR