Protein Info for BWI76_RS22605 in Klebsiella michiganensis M5al

Annotation: Hok/gef cell toxic protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details PF01848: HOK_GEF" amino acids 5 to 46 (42 residues), 63.2 bits, see alignment E=6.7e-22

Best Hits

Swiss-Prot: 86% identical to HOKG_ECO57: Putative protein HokG (hokG) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 90% identity to kva:Kvar_0970)

Predicted SEED Role

"HokE protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (50 amino acids)

>BWI76_RS22605 Hok/gef cell toxic protein (Klebsiella michiganensis M5al)
MLTKYALVAIIVLCFTVLGLTLLVCSSLCELSIKERSMEFKAVLAYESKK