Protein Info for BWI76_RS22480 in Klebsiella michiganensis M5al
Annotation: lactaldehyde reductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 70% identical to FUCO_ECO57: Lactaldehyde reductase (fucO) from Escherichia coli O157:H7
KEGG orthology group: K00048, lactaldehyde reductase [EC: 1.1.1.77] (inferred from 78% identity to pct:PC1_0621)MetaCyc: 70% identical to L-1,2-propanediol oxidoreductase (Escherichia coli K-12 substr. MG1655)
Lactaldehyde reductase. [EC: 1.1.1.77]; 1.1.1.77 [EC: 1.1.1.77]
Predicted SEED Role
"Lactaldehyde reductase (EC 1.1.1.77)" in subsystem L-fucose utilization or L-rhamnose utilization (EC 1.1.1.77)
MetaCyc Pathways
- superpathway of fucose and rhamnose degradation (11/12 steps found)
- superpathway of glycol metabolism and degradation (7/7 steps found)
- ethylene glycol degradation (2/2 steps found)
- L-lactaldehyde degradation (anaerobic) (1/1 steps found)
- nucleoside and nucleotide degradation (halobacteria) (3/6 steps found)
- methylglyoxal degradation VI (1/4 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.77
Use Curated BLAST to search for 1.1.1.77
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285AXH4 at UniProt or InterPro
Protein Sequence (383 amino acids)
>BWI76_RS22480 lactaldehyde reductase (Klebsiella michiganensis M5al) MAYRMILNETSYFGPGSISCIVDEVKKRGFKKALVVTDKDLIRFNVATKVLAILDGAGLP YSIFDDVVPNPTIEVVQQGVETFKQSGADYLIAIGGGSPQDTCKAIGIIINNPEFADVRS LEGGADTKNAAVPMIAIPTTAGTAAEVTINYVITDVQNRRKFVCYDPHDIPLVAIIDAEM MASMPASLKAATGVDALTHAIEGYITKGAWELTDMLHLKAIEVIGRSLRASVQGDAQGAE GMALGQYIAGMGFSNVGLGLVHGMAHPLGAFYGTPHGVANAVLLPHIMAYNAEYTGEKYR DIAVALGNKSAATMPIAEARQAAIEAVAQLNRDVNIPARLRDVGMKEEDIDALAAAALAD VCTGGNPRDTNLEEIKTLYRQIF