Protein Info for BWI76_RS22465 in Klebsiella michiganensis M5al

Annotation: hemin ABC transporter substrate-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 272 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF01497: Peripla_BP_2" amino acids 22 to 247 (226 residues), 93.8 bits, see alignment E=5.8e-31

Best Hits

Swiss-Prot: 53% identical to HMUT_YERPE: Hemin-binding periplasmic protein HmuT (hmuT) from Yersinia pestis

KEGG orthology group: None (inferred from 80% identity to eae:EAE_01765)

Predicted SEED Role

"Periplasmic hemin-binding protein" in subsystem Hemin transport system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AXK9 at UniProt or InterPro

Protein Sequence (272 amino acids)

>BWI76_RS22465 hemin ABC transporter substrate-binding protein (Klebsiella michiganensis M5al)
MKRWLILLAAFPLLASAAAERIVSLGGDVTEVICALDAQRQLVAKDSTSTWPAAAQSLPD
VGYIRQLNAEGILSLRPTLVLASAQAQPSLVLKKVEENKVKVINVPGGYDLPAIEAKIAV
IADALGKQSEGNALRQKVHQQIAQIPSQPVNKRVLFILSHGGMNTMVAGKQTAADGAIRA
AGLQNAMQSFDHYRSMSQEGVIASKPDLVVISADGLKGMGGEAGLWKLPGLAQTPAGRHK
QVLVIDDMALLGFGPRTPQEVLALRQKAEQLP