Protein Info for BWI76_RS21800 in Klebsiella michiganensis M5al

Annotation: MASE2 domain/diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 352 transmembrane" amino acids 22 to 41 (20 residues), see Phobius details amino acids 50 to 70 (21 residues), see Phobius details amino acids 88 to 111 (24 residues), see Phobius details amino acids 123 to 141 (19 residues), see Phobius details amino acids 153 to 174 (22 residues), see Phobius details PF05230: MASE2" amino acids 21 to 108 (88 residues), 82.6 bits, see alignment E=1.7e-27 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 187 to 349 (163 residues), 157.8 bits, see alignment E=1e-50 PF00990: GGDEF" amino acids 192 to 345 (154 residues), 150.7 bits, see alignment E=3.1e-48

Best Hits

KEGG orthology group: None (inferred from 88% identity to kpe:KPK_A0039)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (352 amino acids)

>BWI76_RS21800 MASE2 domain/diguanylate cyclase (Klebsiella michiganensis M5al)
MLKNFPDEKYISDRNSSFIKRVFFLRQVGVILCFIPIYSVLQEQSHQKITIALLTLNALT
WPTVAYLASIMSTDMLYTEKKNMILDSFFAGIWIAVMQASPIPSLFIVSVQIADRYAAGG
WKILKPALTWMMLSFLIVWLANDFRYTMDFSIQTVLLSLPLATCYPIVLSVVSRNLSIKL
RKRRELLEMQALMDPGLDLPNRRFFEQKMESAFRATRNKRIHSYLMLIDVDNFKNINDTY
GHEVGDAVLSRISSILRECAGEKDVPARFGGDELAIIVNNSTSQQVLSMVNIIQKKVKDL
SLPSHKDIYCTISIGISCAENKNSIIEWIKEADEMLYQVKRNGKNGYCMQNN