Protein Info for BWI76_RS21110 in Klebsiella michiganensis M5al

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1648 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF17970: bMG1" amino acids 55 to 159 (105 residues), 159.8 bits, see alignment 1e-50 PF21142: A2M_bMG2" amino acids 165 to 283 (119 residues), 172.1 bits, see alignment 2.2e-54 PF11974: bMG3" amino acids 285 to 377 (93 residues), 78.6 bits, see alignment 1.7e-25 PF01835: MG2" amino acids 384 to 475 (92 residues), 75.4 bits, see alignment 2.1e-24 PF17972: bMG5" amino acids 481 to 606 (126 residues), 136.6 bits, see alignment 3.2e-43 PF17962: bMG6" amino acids 633 to 737 (105 residues), 90 bits, see alignment 6.7e-29 PF07703: A2M_BRD" amino acids 755 to 901 (147 residues), 61.8 bits, see alignment E=4.9e-20 PF00207: A2M" amino acids 972 to 1052 (81 residues), 25.9 bits, see alignment 3.9e-09 PF07678: TED_complement" amino acids 1172 to 1273 (102 residues), 30 bits, see alignment 1.6e-10 PF21765: CUB_A2MG" amino acids 1438 to 1499 (62 residues), 103.8 bits, see alignment (E = 2.9e-33) PF17973: bMG10" amino acids 1500 to 1632 (133 residues), 93.3 bits, see alignment E=7.4e-30

Best Hits

Swiss-Prot: 76% identical to A2MG_ECOLI: Alpha-2-macroglobulin (yfhM) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 90% identity to eae:EAE_00735)

Predicted SEED Role

"Alpha-2-macroglobulin"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B7G2 at UniProt or InterPro

Protein Sequence (1648 amino acids)

>BWI76_RS21110 hypothetical protein (Klebsiella michiganensis M5al)
MKPFRLAALSLALLTALSLTGCDDSGKPQAATPAASAATDKASAKPDASQLAALAEKSKG
KALTLLDASEVQLDGASTMVLTFSIPLQPDQDFSRSVHLVDKKSGKVDGAWELAPNLKEL
RLRHLEPKRELIVSVDPTLAALNKATFDSSFEKTITTRDIAPSIGFASRGSLLPGKVVAG
LPVMALNVDNVDVNFFRIKPESLSAFVSQWEYRNSLSNWESDELLKMADLVYTGRFDLNP
ARNTREKLLLPLADIKPLQEPGVYIAVMNQAGRYSYSNAATLFTLSDIGVSAHRYHNRLD
VFTQSLDNGAAQSDIDVQLLNAKGQTLAQAKSDGQGHVTLQTDKEAALLLARKDGQTTLL
DLKLPALDLAEFSIAGAPGFSKQLFMFGPRDLYRPGETVILNALLRDSDGKPLPEQPVKL
EVVQPNGQVIRSTVSKPVNGLYQFTYPLDSGAATGMWHIRASTGDNQPREWDFHVEDFMP
ERMALNLTPQNAPVSPAADVSFAVTGAYLYGAPASGNSLQGKLFLRPLRDAVPALPGFQF
GDIAEENLSRSLDEVQTTLDDRGHAEVTAASQWQESRSPLQVILQASLLESGGRPVTRTV
RQPIWPADTLPGIRPEFALKEVYDYRTDSTVKQPVVDENGAAAFEIVYADAKGEKKAVSG
LQVRLIRERRDYYWNWSDSEGWQSQFDQKDLQEGEESLDISAGQTAKVSFPVEWGSYRLE
VKGPDDVVSSVRFWAGYSWQDNSDGQGAARPDRVTMKLDKPAYKPGDTIKLHIAAPAAGK
GYALVESSEGPLWWQEIDVPAEGMDLSIPVDKAWNRHDLYLSALVIRPGDKSRSATPKRA
VGLLHLPLGDENRRLNMALEAPAKMRPNQPLTVKVKASVKEGEMPKQVNVLLSAVDSGVL
NITDYATPDPWNAFFGQKRYGADIYDIYGQVIEGQGRLASLRFGGDGDELKRGGKPPVNH
VTIIAQQAQPVVLDEKGEGTVTLPIGDFNGELRVMAQAWTADDFGSSEGKTIVAAPVIAE
LNMPRFLASGDTTRLALDLSNLTDKPQTLNVALAASGLLQLEGGEIPSVQLAPGARSTLF
VPVRAHEGFGDGQVNAIISGVNLPGETFTPMQKQWKLGVRPAFPAQTVNSGAVLQPGESW
QAPAAQSEGFSPATLQGQLVFSGKPPLNLARYIRDLKAYPYGCLEQTTSGLFPSLYTNAV
QLKALGISGDSDEKRRAAVDIGISRLLQMQRDDGGFALWDKEGPEEYWLTAYAMDFLVRA
GEQGYSVPTNAVNSGNQRLLRYLQEPGLMTVRYSDDAQASRFAAQAYAALVLARQQKAPL
GALREIWSRHDQARSGLPLLQLGVALKLMGDAPRGDEALKLAMATPRQDAKRWLGDYGSE
LRDDALKLALLEENKLLPEAQNTLLSNLAEEAYGQRWLSTQESNALFLAGRTLQDRPGSW
QAQTSVQAEPLSGDKAQTRNLTGDQLAALQVTNTGQQALWLRLDSSGYPQSAPQPGGNVL
GIERQIFDTQGQQKSLASLRSGELVLVKLEVTAKRNVPDALVVDLLPAGLELENQNLANS
SASLQENGEAVQNLLNQMQQADIQHIEFRDDRFVAAVAINEGQPVTLVYLARAVTPGTYQ
VPQPQVESMYVPQWRATGAASGPLTVAP