Protein Info for BWI76_RS20670 in Klebsiella michiganensis M5al

Annotation: transcriptional regulator PtsJ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 432 PF00392: GntR" amino acids 7 to 69 (63 residues), 61.6 bits, see alignment E=4.6e-21 PF00155: Aminotran_1_2" amino acids 98 to 423 (326 residues), 113.3 bits, see alignment E=1.5e-36

Best Hits

Swiss-Prot: 63% identical to PTSJ_SALTY: Vitamin B6 salvage pathway transcriptional repressor PtsJ (ptsJ) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: None (inferred from 76% identity to kpu:KP1_4015)

Predicted SEED Role

"Predicted transcriptional regulator of pyridoxine metabolism" in subsystem Pyridoxin (Vitamin B6) Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B7B7 at UniProt or InterPro

Protein Sequence (432 amino acids)

>BWI76_RS20670 transcriptional regulator PtsJ (Klebsiella michiganensis M5al)
MIVGKTASEIFDNIRHLVQSGALKPGDILPPVRELAGKLAVNRNTVAAAYKRLVTSGLAV
SQGRNGTAIKTHNTLPALEGGDPSSPLKDISSGNPDPARLANLKHSLGAIALAPRLYGDA
AVEPRLAAWASRWVNPDLEMDAEINLASGAVDALERLLCALLLPGDSVAIEDPCFLSSIN
MLRYAGFHPSPVPVDGEGMQPEPLEEALRNGARAVIITPRAHNPTGCSLSESRARAIREI
LARYPQVLVIVDDHFALLSATPWYSPIAAESQRWALVRSLSKTLGPDIRLAIVASDADTS
AALRLRLNSGSQWVSHLLQDLVIACLNDNAFMASLAETRRHYRQQHEKLIAALASRGITH
LTPGDGLNFWFPLEEPSQPVALRLAHAGWLVREGETFGIREPAHGLRLSLATLSENEINK
LANDLYQILQQQ