Protein Info for BWI76_RS20635 in Klebsiella michiganensis M5al

Annotation: sulfate transporter CysZ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 253 transmembrane" amino acids 31 to 51 (21 residues), see Phobius details amino acids 71 to 93 (23 residues), see Phobius details amino acids 143 to 162 (20 residues), see Phobius details amino acids 168 to 188 (21 residues), see Phobius details amino acids 210 to 241 (32 residues), see Phobius details PF07264: EI24" amino acids 15 to 231 (217 residues), 198.8 bits, see alignment E=5.2e-63

Best Hits

Swiss-Prot: 88% identical to CYSZ_SALTY: Sulfate transporter CysZ (cysZ) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K06203, CysZ protein (inferred from 92% identity to kpu:KP1_4007)

MetaCyc: 87% identical to sulfate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-586

Predicted SEED Role

"Sulfate transporter, CysZ-type" in subsystem Cysteine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B7E0 at UniProt or InterPro

Protein Sequence (253 amino acids)

>BWI76_RS20635 sulfate transporter CysZ (Klebsiella michiganensis M5al)
MVSSSVTTPRSGVYYFSQGWKLIGLPGIRRYVFLPLLVNIILMGGAFWWLFTRLGSWIPS
LMSHVPEWLQWLNYLLWPMVVISILLVFGYFFSTIANWIAAPFSGLLAEQLEARLTGATP
PDVGIFGIMKDVPRIMKREWQKFAWYLPRAIVLLILYFIPGIGQTIAPVLWFLFSAWMLA
IQYCDYPFDNHKVPFKTMRQALRTRKVTNMQFGALTSLFTMIPILNLVILPVAICGATAM
WVDCYRDKHAMWK