Protein Info for BWI76_RS20520 in Klebsiella michiganensis M5al
Annotation: indolepyruvate decarboxylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K04103, indolepyruvate decarboxylase [EC: 4.1.1.74] (inferred from 86% identity to kva:Kvar_1310)Predicted SEED Role
"Pyruvate decarboxylase (EC 4.1.1.1); Alpha-keto-acid decarboxylase (EC 4.1.1.-)" (EC 4.1.1.-, EC 4.1.1.1)
MetaCyc Pathways
- superpathway of anaerobic sucrose degradation (18/19 steps found)
- superpathway of fermentation (Chlamydomonas reinhardtii) (9/9 steps found)
- pyruvate fermentation to ethanol II (2/2 steps found)
- acetaldehyde biosynthesis II (1/1 steps found)
- L-methionine degradation III (2/3 steps found)
- indole-3-acetate biosynthesis VI (bacteria) (2/3 steps found)
- pyruvate fermentation to acetoin (2/3 steps found)
- pyruvate fermentation to acetate VIII (1/2 steps found)
- L-tryptophan degradation VIII (to tryptophol) (2/4 steps found)
- long chain fatty acid ester synthesis (engineered) (2/4 steps found)
- butanol and isobutanol biosynthesis (engineered) (3/8 steps found)
KEGG Metabolic Maps
- 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation
- 1- and 2-Methylnaphthalene degradation
- 3-Chloroacrylic acid degradation
- Ascorbate and aldarate metabolism
- Benzoate degradation via hydroxylation
- Biphenyl degradation
- Fluorene degradation
- Glycolysis / Gluconeogenesis
- Phenylalanine metabolism
- Phenylpropanoid biosynthesis
- Purine metabolism
- Pyruvate metabolism
- Tryptophan metabolism
- Tyrosine metabolism
- Ubiquinone and menaquinone biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 4.1.1.-
Use Curated BLAST to search for 4.1.1.- or 4.1.1.1 or 4.1.1.74
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285B741 at UniProt or InterPro
Protein Sequence (553 amino acids)
>BWI76_RS20520 indolepyruvate decarboxylase (Klebsiella michiganensis M5al) MQPTYTIGDYLLDRLVDCGIDRLFGVPGDYNLQFLDSVIAHRNLGWVGCANELNAAYAAD GYARIKGAGALLTTYGVGELSALNGIAGSYAEHVPVLHIVGAPCTGAQQRGELLHHTLGD GDFSHFSRMSEQITCSQAVLAAGNACHEIDRVLSEMLTHHRPGYLMLPADVAKAKTTPPA HRLLIQGLPADENQLAGFREHAGRMLRSSRRVSLLADFLAQRYGLQNALREWVAKVPVAY ATMLMGKGLFDEQQSGFVGTYSGIASAEETRDAIENADTIICIGTRFTDTITAGFTQHLP LEKTIEIQPFAVRVADRWFSRIPMEKALAILIELSASLAAEWVSPNIQAPGVSGAPEGSL TQKNFWNTVQKQLRPGDIILADQGTAAFGAAALKLPVDATLIVQPLWGSIGFTLPAAYGA QIAAAERRVVLIVGDGAAQLTIQELGSMLRDKQRPLILLLNNEGYTVERAIHGPEQRYND IALWDWNRLPDAFAPDVPSRCWRVTRTQELQEAMNSSVASDRLTLVEVMLPKMDIPDFLR TVTQALEERNSRV