Protein Info for BWI76_RS20320 in Klebsiella michiganensis M5al

Annotation: histidine/lysine/arginine/ornithine ABC transporter ATP-binding protein HisP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 257 PF00005: ABC_tran" amino acids 21 to 181 (161 residues), 121.7 bits, see alignment E=3.6e-39

Best Hits

Swiss-Prot: 93% identical to HISP_ECOLI: Histidine transport ATP-binding protein HisP (hisP) from Escherichia coli (strain K12)

KEGG orthology group: K10017, histidine transport system ATP-binding protein [EC: 3.6.3.21] (inferred from 96% identity to kpu:KP1_3942)

MetaCyc: 52% identical to cystine ABC transporter ATP binding subunit (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-290 [EC: 7.4.2.12]; 7.4.2.12 [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]

Predicted SEED Role

"Histidine ABC transporter, ATP-binding protein HisP (TC 3.A.1.3.1)" in subsystem Arginine and Ornithine Degradation (TC 3.A.1.3.1)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.21

Use Curated BLAST to search for 3.6.3.21 or 7.4.2.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B782 at UniProt or InterPro

Protein Sequence (257 amino acids)

>BWI76_RS20320 histidine/lysine/arginine/ornithine ABC transporter ATP-binding protein HisP (Klebsiella michiganensis M5al)
MSDNKLNVIDLHKRYGEHEVLKGVSLRAKAGDVISIIGSSGSGKSTFLRCINFLEKPSEG
TIVVNGQNIGLVRDKDGQLKVSDKNQLRLLRTRLTMVFQHFNLWSHMTVLENVMEAPIQV
LGLSKQEARDRAVKYLAKVGIDERQQIKYPVHLSGGQQQRVSIARALAMEPDVLLFDEPT
SALDPELVGEVLRIMQQLAEEGKTMVVVTHEMGFARHVSSHVIFLHQGKIEEEGHPDDVF
GNPKSQRLQQFLKGSLK