Protein Info for BWI76_RS20025 in Klebsiella michiganensis M5al

Annotation: HAMP domain-containing histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 471 signal peptide" amino acids 1 to 40 (40 residues), see Phobius details transmembrane" amino acids 170 to 192 (23 residues), see Phobius details PF08521: 2CSK_N" amino acids 21 to 168 (148 residues), 132.4 bits, see alignment E=2.4e-42 PF00512: HisKA" amino acids 247 to 309 (63 residues), 35.2 bits, see alignment E=2e-12 PF02518: HATPase_c" amino acids 358 to 465 (108 residues), 67.7 bits, see alignment E=2.5e-22 PF13581: HATPase_c_2" amino acids 362 to 442 (81 residues), 30.4 bits, see alignment E=6.7e-11

Best Hits

KEGG orthology group: None (inferred from 88% identity to eae:EAE_24295)

Predicted SEED Role

"Tricarboxylate transport sensor protein TctE"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B751 at UniProt or InterPro

Protein Sequence (471 amino acids)

>BWI76_RS20025 HAMP domain-containing histidine kinase (Klebsiella michiganensis M5al)
MRWGKPQSLFAQLLLFLGLPLVLLWGLSAFNSYVSALQAATQAYDRTLLSSARTVAERLV
VRHGRLEVNVPWVVLDSFELNMNDRLYYKVLDPERRVISGFDDLPPMPPSTSRTDLYPAL
AWFYHTEYRGQAIRVARLLQPVNEGGVVGMAEIYIAETLRSRRWLAGQLLFSSWISQGLL
VLLTLVLAGWLLRRVLRPMRQLSALMVRREPGLLTPLPELLPWSETRLLIVAFNRYIDRL
RVMISRQERFSADASHQLKTPLAVLKTQASVALASGDPRLWRESLEAMSGTLNSTILLTE
RLLQLATIKRKEQGEQAFPPVDLQEIVHHSCFSRLQQARSKAIDLGYEGETSTVTIAGDG
VLLSELCANLLDNAIRYTPQGGIVTVSLHRDGEAVLLDVEDSGPGIDDAQIQQALMPFHR
LENVGDNPGAGLGLALVSDIARLHRSHPQLLRSETLGGLKVRLRFLRARSE