Protein Info for BWI76_RS19910 in Klebsiella michiganensis M5al

Annotation: phosphotransferase RcsD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 886 transmembrane" amino acids 12 to 36 (25 residues), see Phobius details amino acids 304 to 325 (22 residues), see Phobius details PF02518: HATPase_c" amino acids 562 to 673 (112 residues), 42.3 bits, see alignment E=1.4e-14 PF16359: RcsD_ABL" amino acids 684 to 785 (102 residues), 137.9 bits, see alignment E=1.9e-44 PF01627: Hpt" amino acids 806 to 870 (65 residues), 48.7 bits, see alignment 1.1e-16

Best Hits

Swiss-Prot: 74% identical to RCSD_ECOLI: Phosphotransferase RcsD (rcsD) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 87% identity to eae:EAE_24215)

Predicted SEED Role

"Two-component sensor protein RcsD (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B707 at UniProt or InterPro

Protein Sequence (886 amino acids)

>BWI76_RS19910 phosphotransferase RcsD (Klebsiella michiganensis M5al)
MTPKKFSLIPGNITRFFILMVIVLLATMGVMIQSAVNTWLKDKSYQVVDVSYDLHKRIDT
WRYATWQIYDNIAATSSSSASETGLQETRLKQDVYYLEKPRRKTEALIFGSHDGSTLEMT
QKISNYLDILWGAETIPWSMYYLNGLDNSLILVSTLPLKDLSSSFKESTISSVVESRRAE
MLLQANTLDERETFSSLRHLAWQNGYYFTLRTTFNQPGHLATVVAFDLPINDLIPPSMSL
ESFRLEPDPSQSVNSNPDKETADIVSINFNGPQIEILTTINTTGMRLVWMVPFSELILES
LQSILLPLLLNIGLLALALFGFTTFRHYSGRKSIVGTAVSSVANNELRAQRAIHEEIVSL
LPLGLLVHDQDANRTVISNPIADHLLPHLNLQNIINMADQHQGVIQATVNNELYEIRQFR
SQVSPRTQIFIIRDQDREVLVNKKLKQAQRLYEKNQLGRTAFMQHIGTALKQPAQTLAEE
AAALGIAESRKLAQHADELVQLVDEIQLANLLESDSWKSAQGLFSIQELIDEVVPEVLPI
IKRKGLQLLINNALPANEQRYGDRDALRRTLLLLIQYSVTTTPIGKITLEVSKDESADDR
LTFRILDTGNGVSANEIDNMHFPFLNETQADLYGKANALTFWLCDRLTRKLGGQLNIKAR
ESLGTRYSLHLKMAASAEESDSGEHLLDEVVILLDVTANEVRRIVTRQLESWGATCITPD
DRITSQQYDLFLTDNPSNLTASGLLLSDDEVRVHKIGPGQLRVNFNISAAMQEAILQLIE
QQLAEEEEHPSSAGSESNAELHASGYYTLFADTVPDDVKRLYNERATGDFAALAQTAHRL
KGAFAMLNLVPGKQLCETLEHLIREKDAQGIEKYISDIDVYVKSLL