Protein Info for BWI76_RS19780 in Klebsiella michiganensis M5al

Annotation: antibiotic ABC transporter substrate-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 601 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF00496: SBP_bac_5" amino acids 98 to 501 (404 residues), 223.6 bits, see alignment E=2.3e-70

Best Hits

Swiss-Prot: 76% identical to YEJA_ECOLI: Uncharacterized protein YejA (yejA) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 83% identity to eae:EAE_24080)

MetaCyc: 76% identical to putative oligopeptide ABC transporter periplasmic binding protein YejA (Escherichia coli K-12 substr. MG1655)
3.6.3.23-RXN [EC: 7.4.2.6]

Predicted SEED Role

"ABC transporter, periplasmic substrate-binding protein"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B6W3 at UniProt or InterPro

Protein Sequence (601 amino acids)

>BWI76_RS19780 antibiotic ABC transporter substrate-binding protein (Klebsiella michiganensis M5al)
MFARISLILLTLFSLQSQAQTIKESDRFAIIGEPKYAAGFTHYDYANPAAPKGGAITLAA
IGTFDNFNRYAMRGNPGIRTESLYDTLFTTSDDEPGSYYPLIAEHARYADDFSWMEITLN
PRARYHDGSPITASDVAFTFQKFMTEGVPQFRLYYKGTRVKAIAPLTVRIDLAAPGKENM
LSLMTLPVMPEKYWKNHKLSDPLSAPPLASGPYRITAWRMGQYITYSRVKDYWAADLPVN
RGRWNFDSLRYDYYLDDNVAFEAFKAGAVDRREENVAKNWATRYVGRNFTHGYIVKDEYT
NTSAQNTQWLAFNIQRPVFSDRRVREAITLAFDFEWMNKALFYGSYSRANSFFQNTEYAA
RDYPDADELALLTPLKKEIPAEVFTQIYRPPISSGDGFARANLLKADAILNQAGWIVKNQ
RRVNAKSGKPLRFELLLPSGSSDRWVLPFQHNLQRLGIVMDIRQVDNSQYSNRKRSRDYD
MMPNVWRATPWPDTGLQVSWDSQYINSSYNASGVQSPAVDQLIAQIIRWQGNKEKLLPLG
RALDRVLTWNYYMLPMWYMAQDRTAYWDKFSFPQTRAIYSSGFENGWYDASKAARLPADR
R