Protein Info for BWI76_RS19690 in Klebsiella michiganensis M5al

Annotation: LysR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 288 PF00126: HTH_1" amino acids 5 to 64 (60 residues), 62.8 bits, see alignment E=2.4e-21 PF03466: LysR_substrate" amino acids 86 to 286 (201 residues), 178.2 bits, see alignment E=1.4e-56

Best Hits

Swiss-Prot: 84% identical to YEIE_ECOL6: Uncharacterized HTH-type transcriptional regulator YeiE (yeiE) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: None (inferred from 93% identity to kpe:KPK_1571)

Predicted SEED Role

"LysR family transcriptional regulator YeiE" in subsystem YeiH

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B6T3 at UniProt or InterPro

Protein Sequence (288 amino acids)

>BWI76_RS19690 LysR family transcriptional regulator (Klebsiella michiganensis M5al)
MHITLRQLEVFAEVLKSGSTTQASQMLALSQSAVSAALTDLEGQLGVQLFDRVGKRLVVN
EHGRLLYPRALALLERALEIEQLFRGDNGAIRVYASSTIGNYILPEIIARYRRDLPDLPL
ELSVGNSQDVINAVADLRVDIGLIEGPCHAADIIAEPWLEDELVVFAAPDSPLLEGEVTL
QRLAEAPWILREHGSGTREIVDYLLLSHLPAFHLGMELGNSEAIKHAVRHGLGISCLSRR
VVAEQLEVGSLVELTIPLPRLTRTLWRIHHRQKHISKALQRFLHYCDV