Protein Info for BWI76_RS19500 in Klebsiella michiganensis M5al

Annotation: osmoprotectant uptake system permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 385 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 40 to 63 (24 residues), see Phobius details amino acids 71 to 90 (20 residues), see Phobius details amino acids 110 to 127 (18 residues), see Phobius details amino acids 138 to 157 (20 residues), see Phobius details amino acids 180 to 203 (24 residues), see Phobius details amino acids 213 to 236 (24 residues), see Phobius details amino acids 246 to 268 (23 residues), see Phobius details amino acids 323 to 347 (25 residues), see Phobius details amino acids 353 to 378 (26 residues), see Phobius details PF00528: BPD_transp_1" amino acids 191 to 374 (184 residues), 84.2 bits, see alignment E=4.9e-28

Best Hits

Swiss-Prot: 65% identical to YEHY_ECOLI: Glycine betaine uptake system permease protein YehY (yehY) from Escherichia coli (strain K12)

KEGG orthology group: K05846, osmoprotectant transport system permease protein (inferred from 80% identity to kva:Kvar_1498)

MetaCyc: 65% identical to glycine betaine ABC transporter membrane subunit YehY (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-283

Predicted SEED Role

"Osmoprotectant ABC transporter permease protein YehY"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B6S1 at UniProt or InterPro

Protein Sequence (385 amino acids)

>BWI76_RS19500 osmoprotectant uptake system permease (Klebsiella michiganensis M5al)
MTIRCGNRVALLLAWLLLLAMALPFINYAPNRLLSGEGRWLWQVWPWLAGGQAAVALLIA
LLSWRSGRLPLLLIFLLADLLLPLLLWGAGRAAVQLAQSGSPLARTSPGSGLWLALALCL
LIASDAVRRLTSRALWRWLLNAQIWLLPALLLGLGALNDLSLLKEYFNRRDVFDDALSQH
LLLLFGTLLPGLLIGLPVGVWLWRYPRWQSPVFAVLNVIQTVPSVALFGLLIAPLAGLAR
EFPSLAQIGVSGTGMTPALIALVLYALLPLVRGVTTGLQQVPREALESAAAMGMSGGQRF
RQIQLPLALPVLLRSLRVVSVQTVGMAVVAALIGAGGFGALVFQGLLSSALDLVLLGVIP
TIALAVVVDALFALWGALLKGEAGD