Protein Info for BWI76_RS19395 in Klebsiella michiganensis M5al

Annotation: adenine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 603 PF01979: Amidohydro_1" amino acids 72 to 354 (283 residues), 86.6 bits, see alignment E=2.1e-28 PF13382: Adenine_deam_C" amino acids 412 to 577 (166 residues), 141.3 bits, see alignment E=2e-45

Best Hits

Swiss-Prot: 89% identical to ADEC_KLEP7: Adenine deaminase (ade) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K01486, adenine deaminase [EC: 3.5.4.2] (inferred from 89% identity to kpn:KPN_02554)

Predicted SEED Role

"Adenine deaminase (EC 3.5.4.2)" in subsystem Purine conversions (EC 3.5.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B6Q2 at UniProt or InterPro

Protein Sequence (603 amino acids)

>BWI76_RS19395 adenine deaminase (Klebsiella michiganensis M5al)
MSSSAETRRRAVQAARGESPFDLLLTDAQIVDMATGEIREADVGIVGDRIASVHPRGSRS
DARERRSLAGCFLSPGLMDTHVHLESSHLPPERYAEIVLAQGTTAVFWDPHELANVLGVE
GVRYAVAASRHLPLQVMVAAPSSVPSTPGLEMSGADFAGAEMATMLAWPEVCGVAEVMDM
HGVLHGSERMQEIIQAGLDSGKLIEGHARGLSGADLQAYLAAGVTSDHELTSAEDALEKL
RAGLTVEIRGSHPYLLPDIVNALKSLPHLSSQITVCTDDVPPDMLLEKGGIIALLNLLIE
HGLPATDVLRFATLNAAIRLQRNDLGLIAAGRRADLVVFDSLEKLAAREVYVAGKLIARA
GALLEPIPSASGVTPPRDTLQMPPLSPADFILRVGAIRHGVARLRHIRGARFTQWGEVEV
QVRDGKVQIPDGFSLIWVKHRHGRHEAKPQIALLEGWGELRGAIATSYSHDSHNLVVLGR
DPDDMALAANRLIESGGGMALSQQGKILAHVAMPIAGMLSDLPATELARQFRELRDLSAE
IADWEPPYRVFKAIEGTCLACNAGPHLTDLGLTDGGTRQIVEPLIESREIPERPEHNNNH
QGA