Protein Info for BWI76_RS19360 in Klebsiella michiganensis M5al

Annotation: glucose dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 249 PF00106: adh_short" amino acids 15 to 202 (188 residues), 195.9 bits, see alignment E=7.6e-62 PF08659: KR" amino acids 19 to 177 (159 residues), 38.6 bits, see alignment E=1.7e-13 PF13561: adh_short_C2" amino acids 21 to 236 (216 residues), 135 bits, see alignment E=4.8e-43

Best Hits

Swiss-Prot: 96% identical to RIDH_KLEAE: Ribitol 2-dehydrogenase (rbtD) from Klebsiella aerogenes

KEGG orthology group: K00039, ribitol 2-dehydrogenase [EC: 1.1.1.56] (inferred from 97% identity to kpu:KP1_3763)

MetaCyc: 96% identical to ribitol dehydrogenase subunit (Klebsiella aerogenes)
Ribitol 2-dehydrogenase. [EC: 1.1.1.56]

Predicted SEED Role

"Ribitol 2-dehydrogenase (EC 1.1.1.56)" in subsystem Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization (EC 1.1.1.56)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.56

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B6P1 at UniProt or InterPro

Protein Sequence (249 amino acids)

>BWI76_RS19360 glucose dehydrogenase (Klebsiella michiganensis M5al)
MNHSVSSMNTSLSGKVAAITGAASGIGLECAKTLLGSGAKVVLIDREGEKLNKIVAELGE
NAFALQVDLMQAEQVDNLLQGILRLAGRLDIFHANAGAYIGGPVAEGDPDVWDRVLHLNI
NAAFRCVRSVLPHLIAQKSGDIIFTSSIAGVVPVIWEPIYTASKFAVQAFVHTTRRQVSQ
YGVRVGAVLPGPVVTALLDDWPKAKMDEALANGSLMQPIEVAESVLFMVTRSKNVTVRDI
VILPNSVDL