Protein Info for BWI76_RS19345 in Klebsiella michiganensis M5al

Annotation: D-arabinitol 4-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 455 PF01232: Mannitol_dh" amino acids 6 to 166 (161 residues), 148.4 bits, see alignment E=2e-47 PF08125: Mannitol_dh_C" amino acids 196 to 439 (244 residues), 297.3 bits, see alignment E=8.8e-93

Best Hits

Swiss-Prot: 96% identical to DALD_KLEPN: D-arabinitol 4-dehydrogenase (dalD) from Klebsiella pneumoniae

KEGG orthology group: K00007, D-arabinitol 4-dehydrogenase [EC: 1.1.1.11] (inferred from 96% identity to kva:Kvar_1520)

Predicted SEED Role

"D-arabinitol 4-dehydrogenase (EC 1.1.1.11)" in subsystem Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization (EC 1.1.1.11)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B6L6 at UniProt or InterPro

Protein Sequence (455 amino acids)

>BWI76_RS19345 D-arabinitol 4-dehydrogenase (Klebsiella michiganensis M5al)
MNNQFTWLHIGLGSFHRAHQAWYLHRLIASGDKRWHIAAGNIRNDAEQVVQALAAQGGRY
VLETVSPEGEREYEEITSIQKLLPWQAGLQPLINEGANPQTKVIAFTVTEGGYYLNTRHQ
LETSNPDLQADLAGECKTIYGTLARILEKRMADNAGPLTLLNCDNVRHNGERFHDGMVEF
LQLTGKQAVIDWMAVNTTCPNTMVDRITPRPAADLPARIKAQTGIDDKAPVMGETFIQWV
VENNFRDERPKLEAVGVEMVASVIPYEEAKIRILNASHSCIAWAGTLIGQQYIHESTLTD
FIYAIADRYVTEDVIPCLGDNGIDLPTYRDVVLKRFTNPYIQDTNQRVAADGFSKIPAMI
APTLQECYQRGVRPEATAMLPALFFVFMEQWHKGTLPYQYQDGILDAQAVHEMFEAQDPV
ALYARNTALFGTLADNADFLALMREKIAAVYTLIK