Protein Info for BWI76_RS19125 in Klebsiella michiganensis M5al

Annotation: uridine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00235: uridine kinase
  • amino acids 5 to 213 (209 residues), 313 bits, E=4.4e-98
• PF00485: PRK
  • amino acids 10 to 199 (190 residues), 157.7 bits, E=1.7e-50

Best Hits

Swiss-Prot: 96% identical to URK_KLEP7: Uridine kinase (udk) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K00876, uridine kinase [EC: 2.7.1.48] (inferred from 96% identity to kpn:KPN_02519)

MetaCyc: 91% identical to uridine/cytidine kinase (Escherichia coli K-12 substr. MG1655)
Uridine kinase. [EC: 2.7.1.213, 2.7.1.48]; 2.7.1.48 [EC: 2.7.1.213, 2.7.1.48]; 2.7.1.48 [EC: 2.7.1.213, 2.7.1.48]; 2.7.1.48 [EC: 2.7.1.213, 2.7.1.48]

Predicted SEED Role

"Uridine kinase (EC 2.7.1.48) [C1]" (EC 2.7.1.48)

MetaCyc Pathways

• superpathway of pyrimidine ribonucleosides salvage (10/10 steps found)
• pyrimidine ribonucleosides salvage I (3/3 steps found)
• nucleoside and nucleotide degradation (archaea) (4/10 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.213 or 2.7.1.48

Sequence Analysis Tools

See A0A285B6L3 at UniProt or InterPro

Protein Sequence (213 amino acids)

>BWI76_RS19125 uridine kinase (Klebsiella michiganensis M5al)
MTDTSHQCVIIGIAGASASGKSLIASTLYRELREQVGDEHIGVIPEDSYYKDQGHLSMEE
RVKTNYDHPSSMDHSLLFQHLQMLRSGQPIELPVYSYVEHTRMPETIHIEPKKVIILEGI
LLLTDARLRNELSFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMAQYQKTVRPMFLQFI
DPSKQYADIIVPRGGKNRIAIDILKAKISQFFE