Protein Info for BWI76_RS19015 in Klebsiella michiganensis M5al

Annotation: lipopolysaccharide biosynthesis protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 490 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 41 to 60 (20 residues), see Phobius details amino acids 80 to 102 (23 residues), see Phobius details amino acids 114 to 133 (20 residues), see Phobius details amino acids 145 to 165 (21 residues), see Phobius details amino acids 171 to 191 (21 residues), see Phobius details amino acids 289 to 314 (26 residues), see Phobius details amino acids 320 to 340 (21 residues), see Phobius details amino acids 360 to 379 (20 residues), see Phobius details amino acids 384 to 406 (23 residues), see Phobius details amino acids 418 to 439 (22 residues), see Phobius details amino acids 445 to 466 (22 residues), see Phobius details PF01943: Polysacc_synt" amino acids 8 to 276 (269 residues), 196 bits, see alignment E=1.4e-61 PF13440: Polysacc_synt_3" amino acids 32 to 322 (291 residues), 225.9 bits, see alignment E=1e-70 PF14667: Polysacc_synt_C" amino acids 326 to 467 (142 residues), 41.4 bits, see alignment E=2.4e-14

Best Hits

Swiss-Prot: 60% identical to WZXC_ECOLI: Lipopolysaccharide biosynthesis protein WzxC (wzxC) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 79% identity to eae:EAE_23475)

MetaCyc: 60% identical to colanic acid repeat unit flippase (Escherichia coli K-12 substr. MG1655)
RXN-22217

Predicted SEED Role

"Lipopolysaccharide biosynthesis protein WzxC" in subsystem Colanic acid biosynthesis

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (490 amino acids)

>BWI76_RS19015 lipopolysaccharide biosynthesis protein (Klebsiella michiganensis M5al)
MSLRDKTVKGAKWSAIATVASIGISFLQITYLAHIVEPHQFGILTISMLVIVIADTISDF
GISNSIIQRKDIAEVELSTLYWLNVVIGFCVFIMVFSLSSYIADLFHQPDIKPLVQVLSF
AFIIIPYGQQYRALLQKELEFSKIGLIETISILIGSGVTMVSAWFHPYAITAIWGYLCMS
VTKTAMFFYVGRKVYKPSLIFKLKSIKSNIKFGAYLTADALVNQLNSNIATVILSRSLGA
IVAGGYNLSYNVAVMPPSRLNPILTRVLFPAFAKIQDDKEKLKENFYKLLSFVGLINFPV
LLGLLVVSHNFVILIFGDKWLFITPILQILCIVGLLRSIGNPIGSLLMAKARVDISFKFN
VFKLVLFIPSIWIGATFFGGVGAALGFLAVQLLNTYLSYFILIKPVLGKSYREYLKSILL
PFILTLPTVLAAWLVGLYAFSSEVIIMLMAQVIVGVIVFFVTIIFSRNSFICEVKRQIIK
NPKIRRFVRA