Protein Info for BWI76_RS18785 in Klebsiella michiganensis M5al

Annotation: exodeoxyribonuclease I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 474 PF00929: RNase_T" amino acids 12 to 187 (176 residues), 98.1 bits, see alignment E=8.5e-32 PF08411: Exonuc_X-T_C" amino acids 211 to 471 (261 residues), 337.6 bits, see alignment E=4.8e-105

Best Hits

Swiss-Prot: 86% identical to EX1_ECOLI: Exodeoxyribonuclease I (sbcB) from Escherichia coli (strain K12)

KEGG orthology group: K01141, exodeoxyribonuclease I [EC: 3.1.11.1] (inferred from 92% identity to kpn:KPN_02469)

MetaCyc: 86% identical to exodeoxyribonuclease I (Escherichia coli K-12 substr. MG1655)
Exodeoxyribonuclease I. [EC: 3.1.11.1]

Predicted SEED Role

"Exodeoxyribonuclease I (EC 3.1.11.1)" in subsystem DNA Repair Base Excision (EC 3.1.11.1)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B652 at UniProt or InterPro

Protein Sequence (474 amino acids)

>BWI76_RS18785 exodeoxyribonuclease I (Klebsiella michiganensis M5al)
MQDSANQPGFLFHDYETFGTSPSLDRPSQFAAIRTDEDLNIVGEPEVFYCRIADDYLPQP
QAVMVTGITPQEANAKGDSEAAFARRVHDLFTVPKTCIVGYNNVRFDDEVTRNIFYRNFY
DPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPENEEGLPSFRLEHLTVANGIEHSNAH
DAMADVYATIAMAKLVKTQQPRLFDYLYAHRNKRKLATLIDVPQIKPLVHVSGMFGAARG
NTSLVAPLAWHPDNRNAVIMVDLAGDIAPLLELDADTLRERLYTPKSELGDLPAVPIKLV
HLNKCPVLAQQNTLRPQDADRLGINIQRCLDNAQLLRANPQVREKVVAIFAEAEPFVPSD
NVDAQLYNGFFSDADRAAMKIVLETEPRNLPALDITFADKRIERLLFNYRARNYPGTLDE
AEQQRWLEHRRQVFTPEFLQAYADELQMLYQQYADDKEKLAQLKALWQYAQDIV