Protein Info for BWI76_RS18515 in Klebsiella michiganensis M5al

Annotation: multidrug transporter AcrB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1020 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 335 to 354 (20 residues), see Phobius details amino acids 361 to 382 (22 residues), see Phobius details amino acids 388 to 413 (26 residues), see Phobius details amino acids 433 to 452 (20 residues), see Phobius details amino acids 464 to 487 (24 residues), see Phobius details amino acids 523 to 545 (23 residues), see Phobius details amino acids 862 to 881 (20 residues), see Phobius details amino acids 888 to 907 (20 residues), see Phobius details amino acids 913 to 935 (23 residues), see Phobius details amino acids 961 to 981 (21 residues), see Phobius details amino acids 987 to 1011 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1012 (1009 residues), 554.8 bits, see alignment E=1.8e-170

Best Hits

KEGG orthology group: None (inferred from 98% identity to kpe:KPK_A0099)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B613 at UniProt or InterPro

Protein Sequence (1020 amino acids)

>BWI76_RS18515 multidrug transporter AcrB (Klebsiella michiganensis M5al)
MDISRQFINNPIRVWLTILLLGIGGIFALLNIGRLEDPAFTIKTAVVITHYPGASAQQVE
EEVTLPLENALQQLPYLDNVSSISSNGLSQITVNIASHYHSSELPQIWDELRRRVGDAAR
QFPPGVASPFVNDDFGDVFGFFFAISGDSFTNPELVRYAEQLRRELVLVPGVGKVAIGGA
IPQQINIDISLAKMAARGITLTQLAAILSRLNVVSNAGEIKSGSESIRLHPTGEFANLDE
LGDLLISPHGSGTATRLRDIATLSRGLSETPASIYHANGRQAVTMGVSFIPGVNVIDVGR
ALESKLEQMSAEKPAGISIDLFYDQAAEVAHSVNGFITNFLMALAIVVGVLLIFMGVRSG
IIIALSLALNVLGTLLIMYLWGIELQRISLGALIIALSMLVDNAIVIVEGVLIARQQGST
LLTAINYVIRRSALPLLGATVIAILAFAPIGLSQDSTGEYCKSLFQVLLISLMLSWFSAL
TITPVLIKWWLFKNQSQPVAQANANPYGGRFYRLYQQALQALLLRKTLTLTIMAALLAAA
IWGFGSVRQNFFPSSNTPIFFVDLWLPYGTDIATTEKMTSDIETTINGQPGVVTTVATVG
QGSMRFILTYSGQRQYSNYAQIMVRMDDQRNINALTQHVDRYIARNYPQVNASTKRVMFG
PSGDSAIEVRIKGPDPDRLRLLASQVGDILSADPATDGVRNDWQNRSKVIRPQYSTALGR
ELGVDKQDIDNALEMNFSGSRAGLYREGADLLPVVVRPPAAERQDANHLNNVLVWSQSRQ
QYIPLSNVVSGFHLEWEDPLILRRDRSRVLTVQTDPDPLSNQTSGDILSRVKPQIDAIAL
PHGYSIEWGGDAENSSEAQQGLFTTLPLGYLVMFVITVLMFSSLKNAVAIWLTVPLALIG
VTPGFLLTGIPFGFMALIGLLSLSGMLIRNGIVLVEEIEQQKQEKGQQEAIIYAATSRLR
PILLTAFTTVLGLAPLLLDVFFQSMAVVIMFGLGFATILTLLVLPVIYACFHNKDMKRQP